• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Eotaxin-3/CCL26 (CCL26) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844512

Background: Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes.… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Eotaxin-3/CCL26, Active Protein
Full Product Name
Eotaxin-3 / CCL26, human recombinant
Product Gene Name
CCL26 active protein
Product Synonym Names
CCL26
Sequence
TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Host
E Coli
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Appearance: Lyophilized powder
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
8.4 kDa
OMIM
604697
3D Structure
ModBase 3D Structure for Q9Y258
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Endotoxin Level
< 0.1 ng/mug of protein (<1EU/mug).
Activity (Specifications/test method)
Determined by its ability to chemoattract human CCR3/HEK 293 cells using a concentration range of 1.0-2.0 mug/ml.
Biological Activity
Determined by its ability to chemoattract human CCR3/HEK 293 cells using a concentration range of 1.0-2.0 mug/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CCL26 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for CCL26 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CCL26 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL26 purchase

MBS844512 is an active protein targeting CCL26. Also known as Eotaxin-3 / CCL26, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL26. It may not necessarily be applicable to this product.

NCBI GI #
5174671
NCBI GeneID
10344
NCBI Accession #
NP_006063.1
UniProt Primary Accession #
Q9Y258
UniProt Secondary Accession #
Q52LV8; A0N0Q5
UniProt Related Accession #
Q9Y258
GenBank Nucleotide #
NM_006072.4
NCBI Official Full Name
C-C motif chemokine 26
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 26
NCBI Official Symbol
CCL26
NCBI Official Synonym Symbols
IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
UniProt Protein Name
C-C motif chemokine 26
UniProt Synonym Protein Names
CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL26
UniProt Synonym Gene Names
SCYA26; MIP-4-alpha; TSC-1
UniProt Entry Name
CCL26_HUMAN
NCBI Protein Information
C-C motif chemokine 26

NCBI Summary for CCL26

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CCL26

CCL26: Chemotactic for eosinophils and basophils. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: positive regulation of actin filament polymerization; cell-cell signaling; positive regulation of endothelial cell proliferation; immune response; inflammatory response; chemotaxis; signal transduction; positive regulation of cell migration
Show more

Research Articles on CCL26

1. The most potent inhibition of RANTES, eotaxin and eotaxin3 as well as MMP9 activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL26 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram

Diseases associated with CCL26 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >91 publications with CCL26 and Inflammation
 Lung Diseases Antibodies  >46 publications with CCL26 and Lung Diseases
 Eosinophilic Esophagitis Antibodies  >25 publications with CCL26 and Eosinophilic Esophagitis
 Necrosis Antibodies  >21 publications with CCL26 and Necrosis
 Cardiovascular Diseases Antibodies  >13 publications with CCL26 and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >6 publications with CCL26 and Congenital Abnormalities
 Hyperplasia Antibodies  >4 publications with CCL26 and Hyperplasia
 Heart Diseases Antibodies  >4 publications with CCL26 and Heart Diseases
 Pneumonia Antibodies  >3 publications with CCL26 and Pneumonia
 Diabetes Mellitus Antibodies  >3 publications with CCL26 and Diabetes Mellitus

Organs/Tissues associated with CCL26 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >44 publications with CCL26 and Lung
 Eye Antibodies  >8 publications with CCL26 and Eye
 Liver Antibodies  >7 publications with CCL26 and Liver
 Muscle Antibodies  >6 publications with CCL26 and Muscle
 Brain Antibodies  >5 publications with CCL26 and Brain
 Intestine Antibodies  >5 publications with CCL26 and Intestine
 Kidney Antibodies  >4 publications with CCL26 and Kidney
 Heart Antibodies  >3 publications with CCL26 and Heart
 Connective Tissue Antibodies  >2 publications with CCL26 and Connective Tissue
 Pancreas Antibodies  >1 publications with CCL26 and Pancreas
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000