CD71/TFRC/TFR (TFRC) Active Protein

Name: TFRC Active Protein; CD71/TFRC/TFR; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844522
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844522

Background: CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD71/TFRC/TFR, Active Protein

Full Product Name

Human CellExp CD71 / TFRC / TFR, human recombinant

Product Gene Name

TFRC active protein

Product Synonym Names

CD71; TFRC; TFR; sTfR; TfR1; Trfr; T9; p90

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=92%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 76 kDa. The predicted N-terminus is Cys 89. DTT-reduced Protein migrates as 80-85 kDa due to glycosylation.

OMIM

190010

3D Structure

ModBase 3D Structure for P02786

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its binding ability in a functional ELISA. Immobilized rhCD71/TFR at 10 mug/ml (100 mul/well) can bind human Transferrin. The EC50 of human Transferrin is 6.4 ng/ml.

Results

Measured by its binding ability in a functional ELISA. Immobilized rhCD71/TFR at 10 mug/ml (100 mul/well) can bind human Transferrin. The EC50 of human Transferrin is 6.4 ng/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TFRC active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and E

Applications Tested/Suitable for TFRC active protein

SDS-PAGE

Other Notes

Small volumes of TFRC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFRC purchase

MBS844522 is an active protein targeting TFRC. Also known as Human CellExp CD71 / TFRC / TFR, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.

NCBI GI #

189458819

NCBI GeneID

7037

NCBI Accession #

NP_001121620.1

UniProt Primary Accession #

P02786

UniProt Secondary Accession #

Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0

UniProt Related Accession #

P02786

GenBank Nucleotide #

NM_001128148.1

NCBI Official Full Name

transferrin receptor protein 1

NCBI Official Synonym Full Names

transferrin receptor

NCBI Official Symbol

TFRC

NCBI Official Synonym Symbols

T9; TR; TFR; p90; CD71; TFR1; TRFR

UniProt Protein Name

Transferrin receptor protein 1

UniProt Synonym Protein Names

T9; p90; CD_antigen: CD71

Protein Family

Transferrin receptor protein

UniProt Gene Name

TFRC

UniProt Synonym Gene Names

TR; TfR; TfR1; Trfr; sTfR

UniProt Entry Name

TFR1_HUMAN

NCBI Protein Information

transferrin receptor protein 1

UniProt Comments for TFRC

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; transferrin transport; positive regulation of bone resorption; regulation of cell growth; osteoclast differentiation; transmembrane transport; regulation of cell proliferation

Research Articles on TFRC

1. The surface levels of three receptors [TfR, epidermal growth factor receptor (EGFR) and beta1 integrin] were tested and found to be reduced dependent on Escherichia coli EspG translocation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFRC active protein

Reference Product	PubMed Publications
HFE active protein	>21 publications with TFRC and HFE
MYC active protein	>14 publications with TFRC and MYC
B2M active protein	>13 publications with TFRC and B2M
SLC40A1 active protein	>10 publications with TFRC and SLC40A1
FTH1 active protein	>3 publications with TFRC and FTH1
HIF1A active protein	>3 publications with TFRC and HIF1A
UBC active protein	>2 publications with TFRC and UBC
STEAP3 active protein	>1 publications with TFRC and STEAP3

Diseases associated with TFRC active protein

Disease Name	Pubmed Publications
Iron Metabolism Disorders Antibodies	>31 publications with TFRC and Iron Metabolism Disorders
Disease Models, Animal Antibodies	>15 publications with TFRC and Disease Models, Animal
Anemia, Iron-Deficiency Antibodies	>11 publications with TFRC and Anemia, Iron-Deficiency
Inflammation Antibodies	>11 publications with TFRC and Inflammation
Lung Neoplasms Antibodies	>9 publications with TFRC and Lung Neoplasms
Liver Diseases Antibodies	>9 publications with TFRC and Liver Diseases
Breast Neoplasms Antibodies	>7 publications with TFRC and Breast Neoplasms
Colorectal Neoplasms Antibodies	>6 publications with TFRC and Colorectal Neoplasms
Cardiovascular Diseases Antibodies	>6 publications with TFRC and Cardiovascular Diseases
Kidney Diseases Antibodies	>6 publications with TFRC and Kidney Diseases

Organs/Tissues associated with TFRC active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>46 publications with TFRC and Blood
Liver Antibodies	>28 publications with TFRC and Liver
Brain Antibodies	>27 publications with TFRC and Brain
Lung Antibodies	>15 publications with TFRC and Lung
Intestine Antibodies	>13 publications with TFRC and Intestine
Bone Antibodies	>13 publications with TFRC and Bone
Kidney Antibodies	>10 publications with TFRC and Kidney
Skin Antibodies	>9 publications with TFRC and Skin
Embryonic Tissue Antibodies	>8 publications with TFRC and Embryonic Tissue
Vascular Antibodies	>6 publications with TFRC and Vascular