Human Recombinant PRDX4 Active Protein – Cat# MBS844531

PRDX 4 (PRDX4) Human Recombinant Active Protein

Name: PRDX4 Active Protein; PRDX 4; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS844531
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844531

Background: Peroxiredoxin-4 in humans is encoded by the PRDX4 gene. The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. It is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PRDX 4 (PRDX4), Active Protein

Full Product Name

Human Recombinant PRDX 4

Product Gene Name

PRDX4 active protein

Product Synonym Names

Peroxiredoxin 4; PRX-4; AOE37-2; PRDX4.; Human Recombinant PRDX 4

Sequence

MGSSHHHHHH SSGLVPRGSH MWETEERPRT REEECHFYAG GQVYPGEASR VSVADHSLHL SKAKISKPAP YWEGTAVIDG EFKELKLTDY RGKYLVFFFY PLDFTFVCPT EIIAFGDRLE EFRSINTEVV ACSVDSQFTH LAWINTPRRQ GGLGPIRIPL LSDLTHQISK DYGVYLEDSG HTLRGLFIID DKGILRQITL NDLPVGRSVD ETLRLVQAFQ YTDKHGEVCP AGWKPGSETI IPDPAGKLKY FDKLN

Host

E Coli

Form/Format

1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Appearance: Liquid

Purity/Purification

>=90%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

28.8 kDa

OMIM

300927

3D Structure

ModBase 3D Structure for Q13162

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity: approximately 230-310 pmole/min/ug. Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX 4 and peroxide for 20 min at room temperature.

Unit Definition

Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25 degree C for 1 minute.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PRDX4 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for PRDX4 active protein

SDS-PAGE

Other Notes

Small volumes of PRDX4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX4 purchase

MBS844531 is an active protein targeting PRDX4. Also known as Human Recombinant PRDX 4. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX4. It may not necessarily be applicable to this product.

NCBI GI #

5453549

NCBI GeneID

10549

NCBI Accession #

NP_006397.1

UniProt Primary Accession #

Q13162

UniProt Secondary Accession #

Q6FHT3

UniProt Related Accession #

Q13162

GenBank Nucleotide #

NM_006406.1

NCBI Official Full Name

peroxiredoxin-4

NCBI Official Synonym Full Names

peroxiredoxin 4

NCBI Official Symbol

PRDX4

NCBI Official Synonym Symbols

PRX-4; AOE372; AOE37-2; HEL-S-97n

UniProt Protein Name

Peroxiredoxin-4

UniProt Synonym Protein Names

Antioxidant enzyme AOE372; AOE37-2; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX4

UniProt Synonym Gene Names

AOE37-2; Prx-IV

UniProt Entry Name

PRDX4_HUMAN

NCBI Protein Information

peroxiredoxin-4

NCBI Summary for PRDX4

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

UniProt Comments for PRDX4

PRDX4: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Belongs to the AhpC/TSA family.

Protein type: Mitochondrial; Secreted; Oxidoreductase; Secreted, signal peptide; EC 1.11.1.15

Chromosomal Location of Human Ortholog: Xp22.11

Cellular Component: extracellular space; smooth endoplasmic reticulum; mitochondrion; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; thioredoxin peroxidase activity

Biological Process: extracellular matrix organization and biogenesis; protein maturation via protein folding; 4-hydroxyproline metabolic process; cell redox homeostasis; male gonad development; spermatogenesis; I-kappaB phosphorylation

Research Articles on PRDX4

1. Findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX4 active protein

Reference Product	PubMed Publications
PRDX5 active protein	>6 publications with PRDX4 and PRDX5
TXNDC5 active protein	>1 publications with PRDX4 and TXNDC5
GPX4 active protein	>1 publications with PRDX4 and GPX4
ERP44 active protein	>1 publications with PRDX4 and ERP44

Pathways associated with PRDX4 active protein

Products by Pathway	Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with PRDX4 active protein

Disease Name	Pubmed Publications
Prostatic Diseases Antibodies	>7 publications with PRDX4 and Prostatic Diseases
Prostatic Neoplasms Antibodies	>7 publications with PRDX4 and Prostatic Neoplasms
Adenocarcinoma Antibodies	>7 publications with PRDX4 and Adenocarcinoma
Disease Progression Antibodies	>7 publications with PRDX4 and Disease Progression
Nervous System Diseases Antibodies	>6 publications with PRDX4 and Nervous System Diseases
Liver Diseases Antibodies	>4 publications with PRDX4 and Liver Diseases
Inflammation Antibodies	>3 publications with PRDX4 and Inflammation
Lung Neoplasms Antibodies	>3 publications with PRDX4 and Lung Neoplasms
Breast Neoplasms Antibodies	>3 publications with PRDX4 and Breast Neoplasms
Fatty Liver Antibodies	>2 publications with PRDX4 and Fatty Liver

Organs/Tissues associated with PRDX4 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with PRDX4 and Blood
Brain Antibodies	>9 publications with PRDX4 and Brain
Liver Antibodies	>7 publications with PRDX4 and Liver
Prostate Antibodies	>6 publications with PRDX4 and Prostate
Bone Antibodies	>6 publications with PRDX4 and Bone
Lung Antibodies	>5 publications with PRDX4 and Lung
Pancreas Antibodies	>4 publications with PRDX4 and Pancreas
Bone Marrow Antibodies	>4 publications with PRDX4 and Bone Marrow
Vascular Antibodies	>4 publications with PRDX4 and Vascular
Muscle Antibodies	>3 publications with PRDX4 and Muscle