TNFRSF12A Active Protein – Cat# MBS844534

TWEAK Receptor (TNFRSF12A) Active Protein

Name: TNFRSF12A Active Protein; TWEAK Receptor; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844534
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844534

Background: TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TWEAK Receptor (TNFRSF12A), Active Protein

Full Product Name

TWEAK Receptor, human recombinant

Product Gene Name

TNFRSF12A active protein

Product Synonym Names

TNF-related weak inducer of apoptosis receptor; TNFRSF12A; FGF-inducible 14; TWEAKR

Sequence

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5 and 50 mM NaCl.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

5.6 kDa

OMIM

605914

3D Structure

ModBase 3D Structure for Q9NP84

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 mug/ml.

Biological Activity

Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 mug/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TNFRSF12A active protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and Enzymes (A-Z) Apoptosis

Applications Tested/Suitable for TNFRSF12A active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of TNFRSF12A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF12A purchase

MBS844534 is an active protein targeting TNFRSF12A. Also known as TWEAK Receptor, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.

NCBI GI #

7706186

NCBI GeneID

51330

NCBI Accession #

NP_057723.1

UniProt Primary Accession #

Q9NP84

UniProt Secondary Accession #

Q9HCS0; D3DUA6

UniProt Related Accession #

Q9NP84

GenBank Nucleotide #

NM_016639.2

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 12A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 12A

NCBI Official Symbol

TNFRSF12A

NCBI Official Synonym Symbols

FN14; CD266; TWEAKR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 12A

UniProt Synonym Protein Names

Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF12A

UniProt Synonym Gene Names

FN14; FGF-inducible 14; TweakR

UniProt Entry Name

TNR12_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 12A

UniProt Comments for TNFRSF12A

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell development/differentiation; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; substrate-bound cell migration, cell attachment to substrate; positive regulation of axon extension; angiogenesis; regulation of angiogenesis

Research Articles on TNFRSF12A

1. TweakR protein was expressed in about half of human breast cancer samples

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF12A active protein

Reference Product	PubMed Publications
TNFSF12 active protein	>5 publications with TNFRSF12A and TNFSF12
EDN1 active protein	>2 publications with TNFRSF12A and EDN1

Pathways associated with TNFRSF12A active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
TNF Receptor Superfamily (TNFSF) Members Mediating Non-canonical NF-kB Pathway antibodies	TNF Receptor Superfamily (TNFSF) Members Mediating Non-canonical NF-kB Pathway Diagram
TNFR2 Non-canonical NF-kB Pathway antibodies	TNFR2 Non-canonical NF-kB Pathway Diagram
TWEAK Signaling Pathway antibodies	TWEAK Signaling Pathway Diagram

Diseases associated with TNFRSF12A active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>14 publications with TNFRSF12A and Necrosis
Inflammation Antibodies	>10 publications with TNFRSF12A and Inflammation
Death Antibodies	>8 publications with TNFRSF12A and Death
Neoplasms, Experimental Antibodies	>4 publications with TNFRSF12A and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with TNFRSF12A and Lung Neoplasms
Adenocarcinoma Antibodies	>3 publications with TNFRSF12A and Adenocarcinoma
Cardiovascular Diseases Antibodies	>3 publications with TNFRSF12A and Cardiovascular Diseases
Lung Diseases Antibodies	>3 publications with TNFRSF12A and Lung Diseases
Heart Diseases Antibodies	>2 publications with TNFRSF12A and Heart Diseases
Disease Models, Animal Antibodies	>2 publications with TNFRSF12A and Disease Models, Animal

Organs/Tissues associated with TNFRSF12A active protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>7 publications with TNFRSF12A and Vascular
Lung Antibodies	>7 publications with TNFRSF12A and Lung
Muscle Antibodies	>5 publications with TNFRSF12A and Muscle
Blood Antibodies	>4 publications with TNFRSF12A and Blood
Eye Antibodies	>3 publications with TNFRSF12A and Eye
Kidney Antibodies	>2 publications with TNFRSF12A and Kidney
Heart Antibodies	>2 publications with TNFRSF12A and Heart
Liver Antibodies	>2 publications with TNFRSF12A and Liver
Bone Antibodies	>2 publications with TNFRSF12A and Bone
Brain Antibodies	>1 publications with TNFRSF12A and Brain