BPTF Recombinant Protein – Cat# MBS844552

BPTF Bromodomain (BPTF) Recombinant Protein

Name: BPTF Recombinant Protein; BPTF Bromodomain; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844552
Price: 765 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844552

Background: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BPTF bromodomain, Recombinant Protein

Full Product Name

BPTF bromodomain (2796-2907 aa) (GST-tagged), Human recombinant

Product Gene Name

BPTF recombinant protein

Product Synonym Names

Bromodomain PHD Finger Transcription Factor; BPTF bromodomain (2796-2907 aa) (GST-tagged); Human recombinant

Host

E Coli

Form/Format

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM beta-mercaptoethanol and 5% glycerol.
Appearance: Liquid

Purity/Purification

>=80%

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

40.1 kDa (2796-2907 aa + NT GST Tag)

Sequence Positions

2796-2907

OMIM

601819

3D Structure

ModBase 3D Structure for Q12830

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for BPTF recombinant protein

Epigenetics; Bromodomains; Bromodomain Proteins (New category) Epigenetics; Recombinant ProteinsProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for BPTF recombinant protein

SDS-PAGE; HPLC

Other Notes

Small volumes of BPTF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BPTF purchase

MBS844552 is a recombinant protein targeting BPTF. Also known as BPTF bromodomain (2796-2907 aa) (GST-tagged), Human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BPTF. It may not necessarily be applicable to this product.

NCBI GI #

38788260

NCBI GeneID

2186

NCBI Accession #

NP_004450.3

UniProt Primary Accession #

Q12830

UniProt Secondary Accession #

Q6NX67; Q7Z7D6; Q9UIG2

UniProt Related Accession #

Q12830

GenBank Nucleotide #

NM_004459.6

NCBI Official Full Name

nucleosome-remodeling factor subunit BPTF isoform 2

NCBI Official Synonym Full Names

bromodomain PHD finger transcription factor

NCBI Official Symbol

BPTF

NCBI Official Synonym Symbols

FAC1; FALZ; NURF301

UniProt Protein Name

Nucleosome-remodeling factor subunit BPTF

UniProt Synonym Protein Names

Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen

Protein Family

Nucleosome-remodeling factor

UniProt Gene Name

BPTF

UniProt Synonym Gene Names

FAC1; FALZ

UniProt Entry Name

BPTF_HUMAN

NCBI Protein Information

nucleosome-remodeling factor subunit BPTF

NCBI Summary for BPTF

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

UniProt Comments for BPTF

FALZ: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Belongs to the PBTF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor binding

Biological Process: anterior/posterior pattern formation; chromatin remodeling; embryonic placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; brain development; endoderm development

Research Articles on BPTF

1. expression may be marker for survival prediction in hepatocellular carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BPTF recombinant protein

Reference Product	PubMed Publications
SETD1A recombinant protein	>1 publications with BPTF and SETD1A
SMARCA1 recombinant protein	>1 publications with BPTF and SMARCA1
SMARCA5 recombinant protein	>1 publications with BPTF and SMARCA5

Diseases associated with BPTF recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with BPTF and Liver Diseases
Anemia Antibodies	>1 publications with BPTF and Anemia
Hemorrhage Antibodies	>1 publications with BPTF and Hemorrhage
Cell Transformation, Neoplastic Antibodies	>1 publications with BPTF and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>1 publications with BPTF and Nervous System Diseases
Inflammation Antibodies	>1 publications with BPTF and Inflammation
Urinary Bladder Neoplasms Antibodies	>1 publications with BPTF and Urinary Bladder Neoplasms

Organs/Tissues associated with BPTF recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>16 publications with BPTF and Nerve
Embryonic Tissue Antibodies	>4 publications with BPTF and Embryonic Tissue
Blood Antibodies	>3 publications with BPTF and Blood
Testis Antibodies	>3 publications with BPTF and Testis
Bladder Antibodies	>3 publications with BPTF and Bladder
Prostate Antibodies	>2 publications with BPTF and Prostate
Lung Antibodies	>2 publications with BPTF and Lung
Skin Antibodies	>2 publications with BPTF and Skin
Brain Antibodies	>2 publications with BPTF and Brain
Vascular Antibodies	>1 publications with BPTF and Vascular