Apoa-1 (APOA-I) Recombinant Protein

APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Motility/polarity/chemotaxis; Transporter; Cell development/differentiation; Endoplasmic reticulum; Vesicle; Inhibitor; Lipid-binding; G protein, monomeric, non-Rab; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; chylomicron; cell surface; endocytic vesicle; extracellular region; cytoplasmic vesicle; nucleus; vesicle

Molecular Function: lipid transporter activity; identical protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; cholesterol transporter activity; chemorepellent activity; beta-amyloid binding; cholesterol binding; phospholipid binding; phosphatidylcholine binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; lipid binding; apolipoprotein receptor binding

Biological Process: blood vessel endothelial cell migration; negative chemotaxis; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; phosphatidylcholine metabolic process; negative regulation of interleukin-1 beta secretion; sequestering of lipid; protein localization; phospholipid efflux; regulation of cholesterol absorption; negative regulation of hydrolase activity; transforming growth factor beta receptor signaling pathway; phospholipid metabolic process; positive regulation of stress fiber formation; response to nutrient; phospholipid homeostasis; response to drug; integrin-mediated signaling pathway; positive regulation of fatty acid biosynthetic process; cholesterol metabolic process; organ regeneration; regulation of protein amino acid phosphorylation; regulation of Cdc42 protein signal transduction; cholesterol transport; protein amino acid oxidation; protein stabilization; negative regulation of heterotypic cell-cell adhesion; adrenal gland development; axon regeneration; positive regulation of hydrolase activity; positive regulation of Rho protein signal transduction; cholesterol efflux; lipoprotein metabolic process; positive regulation of transferase activity; vitamin transport; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; cholesterol homeostasis; reverse cholesterol transport; lipoprotein biosynthetic process; response to estrogen stimulus; peptidyl-methionine modification; endothelial cell proliferation; negative regulation of inflammatory response; phosphatidylcholine biosynthetic process; positive regulation of lipoprotein lipase activity; phospholipid transport