BMP-9/GDF-2 (GDF2) Active Protein

Name: GDF2 Active Protein; BMP-9/GDF-2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844565
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844565

Background: GDF-2 belongs to the TGF-beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in non-parenchymal cells… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BMP-9/GDF-2 (GDF2), Active Protein

Full Product Name

BMP-9 / GDF-2, human recombinant

Product Gene Name

GDF2 active protein

Product Synonym Names

Growth/Differentiation Factor-2; BMP-9

Sequence

SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK E YEAYECKGGC FFPLADDVTP TK HAIVQTLVHL KFPTKVGKAC CVPTKLSPIS VLYKDDMGVP TLKYHYEGMS VAECGCR

Host

CHO Cells

Form/Format

Lyophilized
Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

Purity/Purification

>=95% by SDS-PAGE gel and HPLC analysis

Preparation and Storage

Store at -20 degree C.
After reconstitution , aliquot and store at -20°C to -80°C
Avoid repeated freezing and thawing cycles.

Molecular Weight

24.1 kDa

OMIM

605120

3D Structure

ModBase 3D Structure for Q9UK05

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin level

<0.1 ng/ug of protein (<1EU/ug)

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Biological Activity

Determined by its ability to induce alkiline phosphatase production by ATDC-5 cells. The expected ED₅₀ for this effect is 0.5-1.9 ng/mL.

Product Categories/Family for GDF2 active protein

Cytokines; Growth Factors & Hormones; BMPsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; BMPs Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growt

Applications Tested/Suitable for GDF2 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of GDF2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF2 purchase

MBS844565 is an active protein targeting GDF2. Also known as BMP-9 / GDF-2, human recombinant. Host: CHO Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF2. It may not necessarily be applicable to this product.

NCBI GI #

7705308

NCBI GeneID

2658

NCBI Accession #

NP_057288.1

UniProt Primary Accession #

Q9UK05

UniProt Secondary Accession #

Q5VSQ9; Q9Y571

UniProt Related Accession #

Q9UK05

GenBank Nucleotide #

NM_016204.2

NCBI Official Full Name

growth/differentiation factor 2 preproprotein

NCBI Official Synonym Full Names

growth differentiation factor 2

NCBI Official Symbol

GDF2

NCBI Official Synonym Symbols

BMP9; HHT5; BMP-9

UniProt Protein Name

Growth/differentiation factor 2

UniProt Synonym Protein Names

Bone morphogenetic protein 9; BMP-9

Protein Family

Growth/differentiation factor

UniProt Gene Name

GDF2

UniProt Synonym Gene Names

BMP9; GDF-2; BMP-9

UniProt Entry Name

GDF2_HUMAN

NCBI Protein Information

growth/differentiation factor 2

NCBI Summary for GDF2

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]

UniProt Comments for GDF2

GDF2: Could be involved in bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: extracellular space

Molecular Function: protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: ossification; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; negative regulation of blood vessel endothelial cell migration; positive regulation of interleukin-8 production; BMP signaling pathway; patterning of blood vessels; regulation of apoptosis; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; negative regulation of angiogenesis; positive regulation of endothelial cell differentiation; negative regulation of DNA replication; regulation of MAPKKK cascade; cartilage development; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of cell growth; angiogenesis; vasculogenesis; cell development; positive regulation of BMP signaling pathway; growth

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5

Research Articles on GDF2

1. This review summarizes the indirect connection between BMP9 and liver fibrosis, with a focus on the BMP9 signaling pathway members ALK1, endoglin, Id1, hepcidin and Snail. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF2 active protein

Reference Product	PubMed Publications
ACVRL1 active protein	>21 publications with GDF2 and ACVRL1
HEY1 active protein	>3 publications with GDF2 and HEY1

Diseases associated with GDF2 active protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>3 publications with GDF2 and Lung Diseases
Neoplasm Metastasis Antibodies	>2 publications with GDF2 and Neoplasm Metastasis
Liver Neoplasms Antibodies	>2 publications with GDF2 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with GDF2 and Carcinoma, Hepatocellular
Pulmonary Fibrosis Antibodies	>1 publications with GDF2 and Pulmonary Fibrosis
Heart Diseases Antibodies	>1 publications with GDF2 and Heart Diseases
Heart Failure Antibodies	>1 publications with GDF2 and Heart Failure
Fibrosis Antibodies	>1 publications with GDF2 and Fibrosis
Inflammation Antibodies	>1 publications with GDF2 and Inflammation

Organs/Tissues associated with GDF2 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>9 publications with GDF2 and Liver