Gm-CSF (CSF2) Active Protein

Name: CSF2 Active Protein; Gm-CSF; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844573
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844573

Background: Rat GM-CSF (Granulocyte Macrophage Colony stimulating Factor) is a potent species-specific stimulator of bone marrow cells. GM-CSF stimulates precursor cells of granulocytes, macrophages and eosinophils. Recombinant rat GM-CSF is a 14.5 kDa… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GM-CSF (CSF2), Active Protein

Full Product Name

GM-CSF, rat recombinant

Product Gene Name

CSF2 active protein

Product Synonym Names

Granulocyte/Macrophage Colony-Stimulating Factor; CSF-2; MGI-1GM; pluripoietin-alpha; Colony-stimulating factor; Molgramostin; Sargramostim

Host

E Coli

Form/Format

Sterile filtered and lyophilized from 10 mM Tris, pH 8.5.
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

14.5 kDa

3D Structure

ModBase 3D Structure for P48750

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4 degree C for 1 week or -20 degree C for future use.

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is <0.01 ng/ml, corresponding to a specific activity of >1 x 10? units/mg.

Results

<0.01 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for CSF2 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of CSF2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSF2 purchase

MBS844573 is an active protein targeting CSF2. Also known as GM-CSF, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CSF2. It may not necessarily be applicable to this product.

NCBI GI #

449083355

NCBI GeneID

116630

NCBI Accession #

NP_446304.1

UniProt Primary Accession #

P48750

UniProt Related Accession #

P48750

GenBank Nucleotide #

NM_053852.1

NCBI Official Full Name

granulocyte-macrophage colony-stimulating factor

NCBI Official Synonym Full Names

colony stimulating factor 2 (granulocyte-macrophage)

NCBI Official Symbol

Csf2

NCBI Official Synonym Symbols

Gmcsf; Gm-csf

UniProt Protein Name

Granulocyte-macrophage colony-stimulating factor

UniProt Synonym Protein Names

Colony-stimulating factor; CSF

Protein Family

Granulocyte-macrophage colony-stimulating factor

UniProt Gene Name

Csf2

UniProt Synonym Gene Names

Csfgm; GM-CSF; CSF

UniProt Entry Name

CSF2_RAT

NCBI Protein Information

granulocyte-macrophage colony-stimulating factor

NCBI Summary for CSF2

plays a role in alveolar epithelial fluid transport [RGD, Feb 2006]

UniProt Comments for CSF2

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; epithelial cell proliferation; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of macrophage differentiation; positive regulation of DNA replication; regulation of cell proliferation

Research Articles on CSF2

1. Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CSF2 active protein

Reference Product	PubMed Publications
Ccl2 active protein	>21 publications with CSF2 and Ccl2
Il4 active protein	>19 publications with CSF2 and Il4
Il2 active protein	>11 publications with CSF2 and Il2
Csf2rb active protein	>10 publications with CSF2 and Csf2rb
Csf2ra active protein	>5 publications with CSF2 and Csf2ra
Stat3 active protein	>4 publications with CSF2 and Stat3
Fos active protein	>3 publications with CSF2 and Fos
Jak2 active protein	>3 publications with CSF2 and Jak2

Pathways associated with CSF2 active protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram

Diseases associated with CSF2 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>43 publications with CSF2 and Inflammation
Necrosis Antibodies	>28 publications with CSF2 and Necrosis
Lung Diseases Antibodies	>9 publications with CSF2 and Lung Diseases
Breast Neoplasms Antibodies	>7 publications with CSF2 and Breast Neoplasms
Carcinoma Antibodies	>5 publications with CSF2 and Carcinoma
Neoplasms, Experimental Antibodies	>4 publications with CSF2 and Neoplasms, Experimental
Leukemia, Myeloid, Acute Antibodies	>3 publications with CSF2 and Leukemia, Myeloid, Acute
Arthritis, Rheumatoid Antibodies	>3 publications with CSF2 and Arthritis, Rheumatoid
Anemia Antibodies	>3 publications with CSF2 and Anemia
Lung Neoplasms Antibodies	>3 publications with CSF2 and Lung Neoplasms