SCARB2/CD36L2/LIMP2 (SCARB2) Active Protein

Name: SCARB2 Active Protein; SCARB2/CD36L2/LIMP2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844575
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844575

Background: Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SCARB2/CD36L2/LIMP2, Active Protein

Full Product Name

Human CellExp SCARB2 / CD36L2 / LIMP2, human recombinant

Product Gene Name

SCARB2 active protein

Product Synonym Names

SCARB2; CD36L2; LIMP2; LIMPII; LGP85; CD36; AMRF; EPM4; HLGP85; SR-BII

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in 50 mM Tris, 100 mM glycine, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 72.5 kDa. The predicted N-terminus is Arg 27. DTT-reduced Protein migrates as 90-115 kDa due to glycosylation.

OMIM

254900

3D Structure

ModBase 3D Structure for Q14108

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 ug/ml (100 ul/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 ug/ml.

Results

Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 ug/ml (100 ul/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 ug/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for SCARB2 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; C

Applications Tested/Suitable for SCARB2 active protein

SDS-PAGE

Other Notes

Small volumes of SCARB2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCARB2 purchase

MBS844575 is an active protein targeting SCARB2. Also known as Human CellExp SCARB2 / CD36L2 / LIMP2, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for SCARB2. It may not necessarily be applicable to this product.

NCBI GI #

323714253

NCBI GeneID

950

NCBI Accession #

NP_001191184.1

UniProt Primary Accession #

Q14108

UniProt Secondary Accession #

Q53Y63; B4DKD8; E7EM68

UniProt Related Accession #

Q14108

GenBank Nucleotide #

NM_001204255.1

NCBI Official Full Name

lysosome membrane protein 2 isoform 2

NCBI Official Synonym Full Names

scavenger receptor class B, member 2

NCBI Official Symbol

SCARB2

NCBI Official Synonym Symbols

AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII

UniProt Protein Name

Lysosome membrane protein 2

UniProt Synonym Protein Names

85 kDa lysosomal membrane sialoglycoprotein; LGP85; CD36 antigen-like 2; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2; CD_antigen: CD36

Protein Family

Lysosome membrane protein

UniProt Gene Name

SCARB2

UniProt Synonym Gene Names

CD36L2; LIMP2; LIMPII; LGP85; LIMP II

UniProt Entry Name

SCRB2_HUMAN

NCBI Protein Information

lysosome membrane protein 2

NCBI Summary for SCARB2

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

UniProt Comments for SCARB2

SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: lysosomal lumen; focal adhesion; membrane; lysosomal membrane; integral to membrane

Molecular Function: protein binding; enzyme binding; receptor activity

Biological Process: protein targeting to lysosome; cell adhesion

Disease: Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure

Research Articles on SCARB2

1. a novel mutation in SCARB2 as a cause of progressive myoclonus epilepsy in China

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCARB2 active protein

Reference Product	PubMed Publications
THBS1 active protein	>1 publications with SCARB2 and THBS1

Pathways associated with SCARB2 active protein

Products by Pathway	Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with SCARB2 active protein

Disease Name	Pubmed Publications
EPILEPSY, PROGRESSIVE MYOCLONIC, 4, WITH OR WITHOUT RENAL FAILURE Antibodies	>196753 publications with SCARB2 and EPILEPSY, PROGRESSIVE MYOCLONIC, 4, WITH OR WITHOUT RENAL FAILURE
Disease Models, Animal Antibodies	>12 publications with SCARB2 and Disease Models, Animal
Kidney Diseases Antibodies	>11 publications with SCARB2 and Kidney Diseases
Inflammation Antibodies	>9 publications with SCARB2 and Inflammation
Carcinoma Antibodies	>7 publications with SCARB2 and Carcinoma
Cardiovascular Diseases Antibodies	>6 publications with SCARB2 and Cardiovascular Diseases
Liver Neoplasms Antibodies	>5 publications with SCARB2 and Liver Neoplasms
Edema Antibodies	>4 publications with SCARB2 and Edema
Carcinoma, Hepatocellular Antibodies	>4 publications with SCARB2 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>4 publications with SCARB2 and Liver Diseases

Organs/Tissues associated with SCARB2 active protein

Organ/Tissue Name	Pubmed Publications
Mouth Antibodies	>24 publications with SCARB2 and Mouth
Blood Antibodies	>16 publications with SCARB2 and Blood
Brain Antibodies	>16 publications with SCARB2 and Brain
Liver Antibodies	>15 publications with SCARB2 and Liver
Kidney Antibodies	>13 publications with SCARB2 and Kidney
Muscle Antibodies	>8 publications with SCARB2 and Muscle
Intestine Antibodies	>6 publications with SCARB2 and Intestine
Spinal Cord Antibodies	>6 publications with SCARB2 and Spinal Cord
Ovary Antibodies	>6 publications with SCARB2 and Ovary
Lung Antibodies	>6 publications with SCARB2 and Lung