Il-13 (IL13) Active Protein

Name: IL13 Active Protein; Il-13; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844608
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844608

Background: IL-13 is an immunoregulatory cytokine produced mainly by T helper 2 cells, but also by mast cells and NK cells. IL-13 is a unique cytokine having similar structural features and functional characteristics as IL-4, but only shares ~30% homolog with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-13 (IL13), Active Protein

Full Product Name

IL-13, rat recombinant

Product Gene Name

IL13 active protein

Product Synonym Names

NC30; ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789.

Host

E Coli

Form/Format

Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

12.7 kDa

3D Structure

ModBase 3D Structure for P42203

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells was typically 2-6 ng/ml.

Results

2-6 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL13 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13 purchase

MBS844608 is an active protein targeting IL13. Also known as IL-13, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #

16758680

NCBI GeneID

116553

NCBI Accession #

NP_446280.1

UniProt Primary Accession #

P42203

UniProt Related Accession #

P42203

GenBank Nucleotide #

NM_053828.1

NCBI Official Full Name

interleukin-13

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

Il13

UniProt Protein Name

Interleukin-13

UniProt Synonym Protein Names

T-cell activation protein P600

Protein Family

Interleukin

UniProt Gene Name

Il13

UniProt Synonym Gene Names

Il-13; IL-13

UniProt Entry Name

IL13_RAT

NCBI Protein Information

interleukin-13

NCBI Summary for IL13

cytokine; involved in inflammatory and immune responses [RGD, Feb 2006]

UniProt Comments for IL13

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; regulation of proton transport; microglial cell activation; positive regulation of mast cell degranulation; response to lipopolysaccharide; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; response to mechanical stimulus; positive regulation of B cell proliferation; positive regulation of ion transport; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of NAD(P)H oxidase activity; inflammatory response; positive regulation of macrophage activation

Research Articles on IL13

1. IL-13 significantly enhanced C/EBP-alpha/COX-2 expression and PGE2 production in LPS-treated microglial cells. Paradoxically, IL-13 abolished C/EBP-beta/PPAR-gamma/HO-1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL13 active protein

Reference Product	PubMed Publications
Il4ra active protein	>901 publications with IL13 and Il4ra
Stat6 active protein	>426 publications with IL13 and Stat6
Il13ra1 active protein	>298 publications with IL13 and Il13ra1
Il5 active protein	>127 publications with IL13 and Il5
Gata3 active protein	>102 publications with IL13 and Gata3
Il9 active protein	>27 publications with IL13 and Il9
Il13ra2 active protein	>17 publications with IL13 and Il13ra2
Csf2 active protein	>16 publications with IL13 and Csf2
Il21 active protein	>6 publications with IL13 and Il21

Pathways associated with IL13 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL13 active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>1451 publications with IL13 and Hypersensitivity
Inflammation Antibodies	>1406 publications with IL13 and Inflammation
Asthma Antibodies	>1337 publications with IL13 and Asthma
Hypersensitivity, Immediate Antibodies	>1264 publications with IL13 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>1253 publications with IL13 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>1048 publications with IL13 and Respiratory Hypersensitivity
Necrosis Antibodies	>664 publications with IL13 and Necrosis
Fibrosis Antibodies	>356 publications with IL13 and Fibrosis
Bronchial Hyperreactivity Antibodies	>240 publications with IL13 and Bronchial Hyperreactivity
Dermatitis, Atopic Antibodies	>193 publications with IL13 and Dermatitis, Atopic