Il-28 (IL28) Active Protein

Name: IL28 Active Protein; Il-28; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844627
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844627

Background: IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-28 (IL28), Active Protein

Full Product Name

IL-28, human recombinant

Product Gene Name

IL28 active protein

Product Synonym Names

Interleukin-28A; IL-28A; IFN-Lambda 2; Interferon-Lambda 2; Cytokine ZCYTO20; IL28A; IFNL2; ZCYTO20; Cytokine receptor family 2 member 12. ; Interleukin-28A; IL-28A; IFN-Lambda 2; Interferon-Lambda 2; Cytokine ZCYTO20; IL28A; IFNL2; ZCYTO20.

Host

E Coli

Form/Format

Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein

Purity/Purification

>=85%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

19.6 kDa

OMIM

607401

3D Structure

ModBase 3D Structure for Q8IZJ0

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in sterile dH?O not less than 100 mug/ml. This solution can then be diluted into other aqueous buffers

Endotoxin Level

<0.1 ng/mug

Biological Activity

Test in process

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL28 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL28 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL28 purchase

MBS844627 is an active protein targeting IL28. Also known as IL-28, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL28. It may not necessarily be applicable to this product.

NCBI GI #

26024321

NCBI GeneID

282616

NCBI Accession #

NP_742150.1

UniProt Primary Accession #

Q8IZJ0

UniProt Secondary Accession #

Q45KQ8; Q6VN55; Q8IWL7

UniProt Related Accession #

Q8IZJ0

GenBank Nucleotide #

NM_172138.1

NCBI Official Full Name

interferon lambda-2

NCBI Official Synonym Full Names

interferon, lambda 2

NCBI Official Symbol

IFNL2

NCBI Official Synonym Symbols

IL28A; IL-28A

UniProt Protein Name

Interferon lambda-2

UniProt Synonym Protein Names

Cytokine Zcyto20; Interleukin-28A; IL-28A

UniProt Gene Name

IFNL2

UniProt Synonym Gene Names

IL28A; ZCYTO20; IFN-lambda-2; IL-28A

UniProt Entry Name

IFNL2_HUMAN

NCBI Protein Information

interferon lambda-2

NCBI Summary for IL28

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

UniProt Comments for IL28

IL28A: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: positive regulation of immune response; mucosal immune response; JAK-STAT cascade; defense response to virus

Research Articles on IL28

1. These results show that type III interferons (IFN-lambdas) play a critical protective role in human metapneumovirus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL28 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Type III Interferon Signaling Pathway antibodies	Type III Interferon Signaling Pathway Diagram