Epigen (EPGN) Active Protein

Name: EPGN Active Protein; Epigen; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844651
Price: 320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844651

Background: EPGN is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. EPGN is produced in numerous tissues, including the testis, liver, heart and in certain tumor cells. EPGN is mitogenic for fibroblasts and epithelial cells.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Epigen (EPGN), Active Protein

Full Product Name

Epigen (EPGN), human recombinant

Product Gene Name

EPGN active protein

Product Synonym Names

EPG; Epigen; PRO9904; ALGV3072; FLJ75542; EPGN; Epithelial mitogen.

Host

E Coli

Form/Format

Sterile filtered and lyophilized from 20 mM PBS buffer pH-7.4 containing 130 mM sodium chloride
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

7.9 kDa

3D Structure

ModBase 3D Structure for Q6UW88

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in sterile dH?O not less than 100 mug/ml.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Endotoxin Level

<0.1 ng/mug

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED?? for this effect is 150-300 ng/ml.

Results

150-300 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for EPGN active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of EPGN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPGN purchase

MBS844651 is an active protein targeting EPGN. Also known as Epigen (EPGN), human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for EPGN. It may not necessarily be applicable to this product.

NCBI GI #

401782583

NCBI GeneID

255324

NCBI Accession #

NP_001257918.1

UniProt Primary Accession #

Q6UW88

UniProt Secondary Accession #

A1BMM3; A1BMM4; A1BMM5; A1BMM6; A1BMM7; A1BMM8; A8K090

UniProt Related Accession #

Q6UW88

GenBank Nucleotide #

NM_001270989.1

NCBI Official Full Name

epigen isoform 1

NCBI Official Synonym Full Names

epithelial mitogen

NCBI Official Symbol

EPGN

NCBI Official Synonym Symbols

EPG; PRO9904; ALGV3072

UniProt Protein Name

Epigen

UniProt Synonym Protein Names

Epithelial mitogen; EPG

Protein Family

Epigen

UniProt Gene Name

EPGN

UniProt Synonym Gene Names

EPG

UniProt Entry Name

EPGN_HUMAN

NCBI Protein Information

epigen

NCBI Summary for EPGN

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UniProt Comments for EPGN

Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: growth factor activity; epidermal growth factor receptor binding

Biological Process: positive regulation of MAP kinase activity; positive regulation of epidermal growth factor receptor activity; positive regulation of mitosis; activation of MAPK activity; positive regulation of cell proliferation; MAPKKK cascade; angiogenesis; positive regulation of epithelial cell proliferation

Research Articles on EPGN

1. cloning of a related gene in mouse

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with EPGN active protein

Disease Name	Pubmed Publications
Hyperplasia Antibodies	>3 publications with EPGN and Hyperplasia
Breast Neoplasms Antibodies	>2 publications with EPGN and Breast Neoplasms
Atrophy Antibodies	>2 publications with EPGN and Atrophy
Bone Diseases Antibodies	>2 publications with EPGN and Bone Diseases
Necrosis Antibodies	>2 publications with EPGN and Necrosis
Kidney Diseases Antibodies	>1 publications with EPGN and Kidney Diseases
Nephritis Antibodies	>1 publications with EPGN and Nephritis
Neoplasms, Experimental Antibodies	>1 publications with EPGN and Neoplasms, Experimental
Inflammation Antibodies	>1 publications with EPGN and Inflammation
Prostatic Diseases Antibodies	>1 publications with EPGN and Prostatic Diseases

Organs/Tissues associated with EPGN active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with EPGN and Lung
Brain Antibodies	>1 publications with EPGN and Brain
Uterus Antibodies	>1 publications with EPGN and Uterus