Il-17a (IL17) Active Protein

Name: IL17 Active Protein; Il-17a; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844653
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844653

Background: The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-17A (IL17), Active Protein

Full Product Name

IL-17A, human recombinant

Product Gene Name

IL17 active protein

Product Synonym Names

IL17A/F; IL17 A/F; IL-17A/F Interleukin-17 A/F; Interleukin-17 AF; Cytotoxic T-lymphocyte-associated antigen 8; IL-17; CTLA-8

Host

E Coli

Form/Format

Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

31.0 kDa

OMIM

603149

3D Structure

ModBase 3D Structure for Q16552

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts is < 2 ng/ml, corresponding to a specific activity of > 5 x 10? units/mg.

Results

< 2 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL17 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL17 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17 purchase

MBS844653 is an active protein targeting IL17. Also known as IL-17A, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17. It may not necessarily be applicable to this product.

NCBI GI #

4504651

NCBI GeneID

3605

NCBI Accession #

NP_002181.1

UniProt Primary Accession #

Q16552

UniProt Secondary Accession #

Q5T2P0

UniProt Related Accession #

Q16552

GenBank Nucleotide #

NM_002190.2

NCBI Official Full Name

interleukin-17A

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

IL17A

NCBI Official Synonym Symbols

IL17; CTLA8; IL-17; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Protein Family

Interleukin

UniProt Gene Name

IL17A

UniProt Synonym Gene Names

CTLA8; IL17; IL-17; IL-17A; CTLA-8

UniProt Entry Name

IL17_HUMAN

NCBI Protein Information

interleukin-17A

NCBI Summary for IL17

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

UniProt Comments for IL17

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; apoptosis; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Research Articles on IL17

1. A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL17 active protein

Reference Product	PubMed Publications
FOXP3 active protein	>717 publications with IL17 and FOXP3
STAT3 active protein	>309 publications with IL17 and STAT3
TGFB1 active protein	>159 publications with IL17 and TGFB1
IL6 active protein	>137 publications with IL17 and IL6
IL17RA active protein	>120 publications with IL17 and IL17RA
STAT1 active protein	>93 publications with IL17 and STAT1
TRAF3IP2 active protein	>51 publications with IL17 and TRAF3IP2
IL22 active protein	>34 publications with IL17 and IL22
IL17RC active protein	>27 publications with IL17 and IL17RC
NFKB1 active protein	>4 publications with IL17 and NFKB1

Diseases associated with IL17 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2728 publications with IL17 and Inflammation
Autoimmune Diseases Antibodies	>2021 publications with IL17 and Autoimmune Diseases
Disease Models, Animal Antibodies	>1472 publications with IL17 and Disease Models, Animal
Necrosis Antibodies	>1137 publications with IL17 and Necrosis
Lung Diseases Antibodies	>715 publications with IL17 and Lung Diseases
Central Nervous System Diseases Antibodies	>580 publications with IL17 and Central Nervous System Diseases
Hypersensitivity Antibodies	>559 publications with IL17 and Hypersensitivity
Cardiovascular Diseases Antibodies	>385 publications with IL17 and Cardiovascular Diseases
Colitis Antibodies	>340 publications with IL17 and Colitis
Liver Diseases Antibodies	>217 publications with IL17 and Liver Diseases

Organs/Tissues associated with IL17 active protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>114 publications with IL17 and Mixed