Human Recombinant PPID Active Protein – Cat# MBS844680

Cyclophilin D (PPID) Human Recombinant Active Protein

Name: PPID Active Protein; Cyclophilin D; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS844680
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844680

Background: Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cyclophilin D (PPID), Active Protein

Full Product Name

Human Recombinant Cyclophilin D

Product Gene Name

PPID active protein

Product Synonym Names

Peptidylprolyl isomerase D; PPID; CYPD; CYP-40; Human Recombinant Cyclophilin D

Sequence

MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL

Host

E Coli

Form/Format

1 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Appearance: Liquid

Purity/Purification

>=95%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

42.9 kDa

OMIM

601753

3D Structure

ModBase 3D Structure for Q08752

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 210 nmoles/min/mg

Unit Definition

Specific activity is defined as the amount of enzyme that cleaves 1 umole of Suc-AAFP-pNA per minute at 25 degree C in Tris HCl pH 8.0 using chymotrypsin.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PPID active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for PPID active protein

SDS-PAGE

Other Notes

Small volumes of PPID active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPID purchase

MBS844680 is an active protein targeting PPID. Also known as Human Recombinant Cyclophilin D. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPID. It may not necessarily be applicable to this product.

NCBI GI #

4826932

NCBI GeneID

5481

NCBI Accession #

NP_005029.1

UniProt Primary Accession #

Q08752

UniProt Secondary Accession #

B2R9V2

UniProt Related Accession #

Q08752

GenBank Nucleotide #

NM_005038.2

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase D

NCBI Official Synonym Full Names

peptidylprolyl isomerase D

NCBI Official Symbol

PPID

NCBI Official Synonym Symbols

CYPD; CYP-40

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase D

UniProt Synonym Protein Names

40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

PPID

UniProt Synonym Gene Names

CYP40; CYPD; PPIase D; CYP-40

UniProt Entry Name

PPID_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase D

NCBI Summary for PPID

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

UniProt Comments for PPID

PPID: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Protein type: Nucleolus; EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; heat shock protein binding; estrogen receptor binding; Hsp90 protein binding; Hsp70 protein binding; transcription factor binding; cyclosporin A binding

Biological Process: release of virus from host; protein transport; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; positive regulation of protein secretion; positive regulation of apoptosis; apoptosis; protein complex assembly; negative regulation of transcription from RNA polymerase II promoter

Research Articles on PPID

1. Cyp40 binds to C2I in vitro and in intact cells, it also interacts with the enzyme components of iota toxin and CDT, suggesting a common principle for this toxin family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPID active protein

Reference Product	PubMed Publications
STIP1 active protein	>1 publications with PPID and STIP1
AHSA1 active protein	>1 publications with PPID and AHSA1

Diseases associated with PPID active protein

Disease Name	Pubmed Publications
Death Antibodies	>15 publications with PPID and Death
Necrosis Antibodies	>5 publications with PPID and Necrosis
Inflammation Antibodies	>4 publications with PPID and Inflammation
Hyperplasia Antibodies	>4 publications with PPID and Hyperplasia
Weight Loss Antibodies	>3 publications with PPID and Weight Loss
Cardiovascular Diseases Antibodies	>2 publications with PPID and Cardiovascular Diseases
Fibrosis Antibodies	>2 publications with PPID and Fibrosis
Poisoning Antibodies	>2 publications with PPID and Poisoning
Insulin Resistance Antibodies	>2 publications with PPID and Insulin Resistance
Hemorrhage Antibodies	>2 publications with PPID and Hemorrhage

Organs/Tissues associated with PPID active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>39 publications with PPID and Brain
Blood Antibodies	>38 publications with PPID and Blood
Heart Antibodies	>4 publications with PPID and Heart
Prostate Antibodies	>3 publications with PPID and Prostate
Liver Antibodies	>3 publications with PPID and Liver
Embryonic Tissue Antibodies	>2 publications with PPID and Embryonic Tissue
Lung Antibodies	>2 publications with PPID and Lung
Thyroid Antibodies	>1 publications with PPID and Thyroid
Pancreas Antibodies	>1 publications with PPID and Pancreas
Vascular Antibodies	>1 publications with PPID and Vascular