TFF-3 (TFF3) Active Protein

Name: TFF3 Active Protein; TFF-3; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844683
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844683

Background: Proteins of the TFF family are characterized by having at least 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TFF-3 (TFF3), Active Protein

Full Product Name

TFF-3, human recombinant

Product Gene Name

TFF3 active protein

Product Synonym Names

Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)

Sequence

EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF

Host

E Coli

Form/Format

Sterile filtered white powder lyophilized from a solution containing PBS pH 7.4
Appearance: Lyophilized protein

Purity/Purification

>=97%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

13.2 kDa

OMIM

600633

3D Structure

ModBase 3D Structure for Q07654

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

. Reconstitute in sterile 18 Momega-cm H?O at not less than 100 ug/ml. Reconstituted TFF3 should be stored in working aliquots at -20 degree C.

Biological Activity

Determined by its ability to chemoattract human MCF-7 cells using a concentration 1.0-10.0 ng/ml.

Results

1.0-10.0 ng/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TFF3 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins

Applications Tested/Suitable for TFF3 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of TFF3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFF3 purchase

MBS844683 is an active protein targeting TFF3. Also known as TFF-3, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TFF3. It may not necessarily be applicable to this product.

NCBI GI #

281485608

NCBI GeneID

7033

NCBI Accession #

NP_003217.3

UniProt Primary Accession #

Q07654

UniProt Secondary Accession #

Q96NX0; Q9UDA5; E9PBB5

UniProt Related Accession #

Q07654

GenBank Nucleotide #

NM_003226.3

NCBI Official Full Name

trefoil factor 3

NCBI Official Synonym Full Names

trefoil factor 3 (intestinal)

NCBI Official Symbol

TFF3

NCBI Official Synonym Symbols

ITF; P1B; TFI

UniProt Protein Name

Trefoil factor 3

UniProt Synonym Protein Names

Intestinal trefoil factor; hITF; Polypeptide P1.B; hP1.B

Protein Family

Trefoil factor

UniProt Gene Name

TFF3

UniProt Synonym Gene Names

ITF; TFI; hITF; hP1.B

UniProt Entry Name

TFF3_HUMAN

NCBI Protein Information

trefoil factor 3

NCBI Summary for TFF3

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

UniProt Comments for TFF3

TFF3: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region; secretory granule

Biological Process: response to peptide hormone stimulus; digestion; defense response

Research Articles on TFF3

1. Associations discovered between trefoil factor 3 gene variants and idiopathic recurrent spontaneous abortion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFF3 active protein

Reference Product	PubMed Publications
TFF1 active protein	>212 publications with TFF3 and TFF1
TFF2 active protein	>169 publications with TFF3 and TFF2
EGFR active protein	>13 publications with TFF3 and EGFR
CTNNB1 active protein	>10 publications with TFF3 and CTNNB1
ERBB2 active protein	>7 publications with TFF3 and ERBB2
HIF1A active protein	>4 publications with TFF3 and HIF1A
STAT6 active protein	>4 publications with TFF3 and STAT6
RELA active protein	>1 publications with TFF3 and RELA

Diseases associated with TFF3 active protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>115 publications with TFF3 and Carcinoma
Inflammation Antibodies	>67 publications with TFF3 and Inflammation
Adenocarcinoma Antibodies	>63 publications with TFF3 and Adenocarcinoma
Breast Neoplasms Antibodies	>42 publications with TFF3 and Breast Neoplasms
Hyperplasia Antibodies	>28 publications with TFF3 and Hyperplasia
Necrosis Antibodies	>26 publications with TFF3 and Necrosis
Neoplasm Metastasis Antibodies	>23 publications with TFF3 and Neoplasm Metastasis
Liver Diseases Antibodies	>17 publications with TFF3 and Liver Diseases
Lung Diseases Antibodies	>16 publications with TFF3 and Lung Diseases
Prostatic Neoplasms Antibodies	>14 publications with TFF3 and Prostatic Neoplasms

Organs/Tissues associated with TFF3 active protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>335 publications with TFF3 and Muscle
Intestine Antibodies	>221 publications with TFF3 and Intestine
Stomach Antibodies	>169 publications with TFF3 and Stomach
Liver Antibodies	>46 publications with TFF3 and Liver
Brain Antibodies	>30 publications with TFF3 and Brain
Thyroid Antibodies	>26 publications with TFF3 and Thyroid
Kidney Antibodies	>26 publications with TFF3 and Kidney
Lung Antibodies	>23 publications with TFF3 and Lung
Pancreas Antibodies	>23 publications with TFF3 and Pancreas
Eye Antibodies	>16 publications with TFF3 and Eye