POSTN Recombinant Protein – Cat# MBS844686

Periostin/OSF-2 (POSTN) Recombinant Protein

Name: POSTN Recombinant Protein; Periostin/OSF-2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844686
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844686

Background: Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Periostin/OSF-2 (POSTN), Recombinant Protein

Full Product Name

Periostin / OSF-2, human recombinant

Product Gene Name

POSTN recombinant protein

Product Synonym Names

OSF-2; Periostin; Osteoblast Specific Factor 2; PN OSF-2,PDLPOSTN; POSTN; MGC119510; MGC119511; PN; RP11-412K4.1.

Sequence

MGHHHHHHHH HHSSGHIEGR HMRNNHYDKI LAHSRIRGRD QGPNVCALQQ ILGTKKKYFS TCKNWYKKSI CGQKTTVLYE CCPGYMRMEG MKGCPAVLPI DHVYGTLGIV GATTTQRYSD ASKLREEIEG KGSFTYFAPS NEAWDNLDSD IRRGLESNVN VELLNALHSH MINKRMLTKD LKNGMIIPSM YNNLGLFINH YPNGVVTVNC ARIIHGNQIA TNGVVHVIDR VLTQIGTSIQ DFIEAEDDLS SFRAAAITSD ILEALGRDGH FTLFAPTNEA FEKLPRGVLE RFMGDKVASE ALMKYHILNT LQCSESIMGG AVFETLEGNT IEIGCDGDSI TVNGIKMVNK KDIVTNNGVI HLIDQVLIPD SAKQVIELAG KQQTTFTDLV AQLGLASALR PDGEYTLLAP VNNAFSDDTL SMVQRLLKLI LQNHILKVKV GLNELYNGQI LETIGGKQLR VFVYRTAVCI ENSCMEKGSK QGRNGAIHIF REIIKPAEKS LHEKLKQDKR FSTFLSLLEA ADLKELLTQP GDWTLFVPTN DAFKGMTSEE KEILIRDKNA LQNIILYHLT PGVFIGKGFE PGVTNILKTT QGSKIFLKEV NDTLLVNELK SKESDIMTTN GVIHVVDKLL YPADTPVGND QLLEILNKLI KYIQIKFVRG STFKEIPVTV Y.

Host

E Coli

Form/Format

Solid. Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
Appearance: Lyophilized protein

Purity/Purification

>=90%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

75 kDa

OMIM

608777

3D Structure

ModBase 3D Structure for Q15063

Solubility/Reconstitution Instructions

It is recommended to add 0.1 M Acetate buffer pH 4.0 to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for POSTN recombinant protein

Proteins and Enzymes; Cytokines; Growth Factors & Hormones; MCPsProteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for POSTN recombinant protein

SDS-PAGE; HPLC

Other Notes

Small volumes of POSTN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POSTN purchase

MBS844686 is a recombinant protein targeting POSTN. Also known as Periostin / OSF-2, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for POSTN. It may not necessarily be applicable to this product.

NCBI GI #

209862911

NCBI GeneID

10631

NCBI Accession #

NP_001129406.1

UniProt Primary Accession #

Q15063

UniProt Secondary Accession #

Q15064; Q29XZ0; Q3KPJ5; Q5VSY5; Q8IZF9; B1ALD8; C0IMJ1; C0IMJ2; C0IMJ4; D2KRH7; F5H628

UniProt Related Accession #

Q15063

GenBank Nucleotide #

NM_001135934.1

NCBI Official Full Name

periostin isoform 2

NCBI Official Synonym Full Names

periostin, osteoblast specific factor

NCBI Official Symbol

POSTN

NCBI Official Synonym Symbols

PN; OSF2; OSF-2; PDLPOSTN; periostin

UniProt Protein Name

Periostin

UniProt Synonym Protein Names

Osteoblast-specific factor 2; OSF-2

Protein Family

Periostin

UniProt Gene Name

POSTN

UniProt Synonym Gene Names

OSF2; PN; OSF-2

UniProt Entry Name

POSTN_HUMAN

NCBI Protein Information

periostin

NCBI Summary for POSTN

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

UniProt Comments for POSTN

POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; trans-Golgi network

Molecular Function: heparin binding; protein binding; cell adhesion molecule binding

Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development

Research Articles on POSTN

1. Periostin is exclusively produced by activated pancreatic stellate cells, and periostin overexpression presents in various malignant tumors and closely relates with disease progression. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with POSTN recombinant protein

Reference Product	PubMed Publications
MMP2 recombinant protein	>7 publications with POSTN and MMP2
TNC recombinant protein	>7 publications with POSTN and TNC
BMP4 recombinant protein	>5 publications with POSTN and BMP4
NOTCH1 recombinant protein	>5 publications with POSTN and NOTCH1
BMP1 recombinant protein	>4 publications with POSTN and BMP1
MMP13 recombinant protein	>3 publications with POSTN and MMP13
AKT1 recombinant protein	>1 publications with POSTN and AKT1

Diseases associated with POSTN recombinant protein

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>42 publications with POSTN and Neoplasm Metastasis
Hypertension Antibodies	>9 publications with POSTN and Hypertension
Colorectal Neoplasms Antibodies	>8 publications with POSTN and Colorectal Neoplasms
Carcinoma, Hepatocellular Antibodies	>7 publications with POSTN and Carcinoma, Hepatocellular
Drug Hypersensitivity Antibodies	>7 publications with POSTN and Drug Hypersensitivity
Muscular Dystrophy, Duchenne Antibodies	>4 publications with POSTN and Muscular Dystrophy, Duchenne
Bronchopulmonary Dysplasia Antibodies	>2 publications with POSTN and Bronchopulmonary Dysplasia
Prenatal Exposure Delayed Effects Antibodies	>1 publications with POSTN and Prenatal Exposure Delayed Effects
Edema Antibodies	>1 publications with POSTN and Edema

Organs/Tissues associated with POSTN recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>131 publications with POSTN and Bone
Muscle Antibodies	>80 publications with POSTN and Muscle
Connective Tissue Antibodies	>69 publications with POSTN and Connective Tissue
Vascular Antibodies	>61 publications with POSTN and Vascular
Lung Antibodies	>56 publications with POSTN and Lung
Mouth Antibodies	>55 publications with POSTN and Mouth
Liver Antibodies	>27 publications with POSTN and Liver
Brain Antibodies	>19 publications with POSTN and Brain
Bone Marrow Antibodies	>17 publications with POSTN and Bone Marrow
Kidney Antibodies	>16 publications with POSTN and Kidney