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Netrin-1 (NTN1) Human Cellexp Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844755

Background: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association… More details

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Product Overview

Product Name
Netrin-1 (NTN1), Active Protein
Full Product Name
Human CellExp Netrin-1, human recombinant
Product Gene Name
NTN1 active protein
Product Synonym Names
NTN1
Host
HEK293 cells
Form/Format
Lyophilized in PBS with trehalose and Brij 35.
Appearance: Lyophilized
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 6 months
Molecular Weight
~80.0 kDa. Human netrin-1 (aa 25-604) is fused at the C-terminus to a FLAG-tag.
OMIM
601614
3D Structure
ModBase 3D Structure for O95631
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute with 100 mul sterile distilled water.
Endotoxin Level
<0.1 EU/mug by LAL method
Activity (Specifications/test method)
Induces axon outgrowth.
Biological Activity
Induces axon outgrowth.
Results
Induces axon outgrowth.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for NTN1 active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Other Proteins & EnzymesDiabetes; Obesity & Metabolic Syndrome; Lipids Metabolism; Proteins/Enzymes; Other (NEW)
Applications Tested/Suitable for NTN1 active protein
SDS-PAGE

Other Notes

Small volumes of NTN1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTN1 purchase

MBS844755 is an active protein targeting NTN1. Also known as Human CellExp Netrin-1, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for NTN1. It may not necessarily be applicable to this product.

NCBI GI #
148613884
NCBI GeneID
9423
NCBI Accession #
NP_004813.2
UniProt Primary Accession #
O95631
UniProt Secondary Accession #
E9KL51
UniProt Related Accession #
O95631
GenBank Nucleotide #
NM_004822.2
NCBI Official Full Name
netrin-1
NCBI Official Synonym Full Names
netrin 1
NCBI Official Symbol
NTN1
NCBI Official Synonym Symbols
NTN1L
UniProt Protein Name
Netrin-1
UniProt Synonym Protein Names
Epididymis tissue protein Li 131P
Protein Family
Netrin
UniProt Gene Name
NTN1
UniProt Synonym Gene Names
NTN1L
UniProt Entry Name
NET1_HUMAN
NCBI Protein Information
netrin-1

NCBI Summary for NTN1

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
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UniProt Comments for NTN1

NTN1: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; extracellular region; basement membrane

Molecular Function: protein binding

Biological Process: axon guidance; cell-cell adhesion; inner ear morphogenesis; establishment of nucleus localization; apoptosis; positive regulation of axon extension; positive regulation of cell proliferation; neuron migration; negative regulation of axon extension; regulation of cell migration; anterior/posterior axon guidance
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Research Articles on NTN1

1. early urinary biomarker in the diagnosis of septic acute kidney injury

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NTN1 active protein

 Reference Product  PubMed Publications
 DCC active protein  >7 publications with NTN1 and DCC
 UNC5B active protein  >6 publications with NTN1 and UNC5B
 UNC5C active protein  >2 publications with NTN1 and UNC5C
 UNC5A active protein  >1 publications with NTN1 and UNC5A
 NEO1 active protein  >1 publications with NTN1 and NEO1

Pathways associated with NTN1 active protein

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 DCC Mediated Attractive Signaling Pathway antibodies  DCC Mediated Attractive Signaling Pathway Diagram
 DSCAM Interactions Pathway antibodies  DSCAM Interactions Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Netrin Mediated Repulsion Signals Pathway antibodies  Netrin Mediated Repulsion Signals Pathway Diagram
 Netrin-1 Signaling Pathway antibodies  Netrin-1 Signaling Pathway Diagram

Diseases associated with NTN1 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with NTN1 and Inflammation
 Congenital Abnormalities Antibodies  >3 publications with NTN1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >2 publications with NTN1 and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >2 publications with NTN1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with NTN1 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with NTN1 and Disease Models, Animal
 Atherosclerosis Antibodies  >2 publications with NTN1 and Atherosclerosis
 Neoplasm Metastasis Antibodies  >1 publications with NTN1 and Neoplasm Metastasis
 Death Antibodies  >1 publications with NTN1 and Death
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with NTN1 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with NTN1 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with NTN1 and Brain
 Muscle Antibodies  >3 publications with NTN1 and Muscle
 Embryonic Tissue Antibodies  >3 publications with NTN1 and Embryonic Tissue
 Lung Antibodies  >2 publications with NTN1 and Lung
 Eye Antibodies  >2 publications with NTN1 and Eye
 Connective Tissue Antibodies  >1 publications with NTN1 and Connective Tissue
 Ovary Antibodies  >1 publications with NTN1 and Ovary
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