TECK (CCL25) Active Protein

Name: CCL25 Active Protein; TECK; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844762
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844762

Background: TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. Recombinant human TECK is a 14.2 kDa protein… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TECK (CCL25), Active Protein

Full Product Name

TECK (CCL25), human recombinant

Product Gene Name

CCL25 active protein

Product Synonym Names

Thymus Expressed Chemokine; CCL25

Sequence

QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSRKNVSLL ISANSGL

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Acetic acid.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

14.2 kDa

OMIM

602565

3D Structure

ModBase 3D Structure for O15444

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for CCL25 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok

Applications Tested/Suitable for CCL25 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of CCL25 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL25 purchase

MBS844762 is an active protein targeting CCL25. Also known as TECK (CCL25), human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL25. It may not necessarily be applicable to this product.

NCBI GI #

323098324

NCBI GeneID

6370

NCBI Accession #

NP_001188288.1

UniProt Primary Accession #

O15444

UniProt Secondary Accession #

Q96KJ7; A1L4J4; A6NI52; A8K9E7; B5MCA5

UniProt Related Accession #

O15444

GenBank Nucleotide #

NM_001201359.1

NCBI Official Full Name

C-C motif chemokine 25 isoform 2

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 25

NCBI Official Symbol

CCL25

NCBI Official Synonym Symbols

TECK; Ckb15; SCYA25

UniProt Protein Name

C-C motif chemokine 25

UniProt Synonym Protein Names

Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL25

UniProt Synonym Gene Names

SCYA25; TECK

UniProt Entry Name

CCL25_HUMAN

NCBI Protein Information

C-C motif chemokine 25

NCBI Summary for CCL25

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

UniProt Comments for CCL25

CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Chemokine; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; hormone activity; CCR10 chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; immune response; inflammatory response; positive regulation of cell-matrix adhesion; chemotaxis; leukocyte migration

Research Articles on CCL25

1. TECK derived from endometrial stromal cell and macrophages upregulates the number and function of Tregs in the ectopic milieu.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL25 active protein

Reference Product	PubMed Publications
CCR9 active protein	>145 publications with CCL25 and CCR9
CXCL12 active protein	>42 publications with CCL25 and CXCL12
CCL21 active protein	>35 publications with CCL25 and CCL21
CCL28 active protein	>32 publications with CCL25 and CCL28
CCL19 active protein	>31 publications with CCL25 and CCL19
CCR7 active protein	>20 publications with CCL25 and CCR7
CCR10 active protein	>18 publications with CCL25 and CCR10
CCRL1 active protein	>7 publications with CCL25 and CCRL1
CCL27 active protein	>5 publications with CCL25 and CCL27
CCBP2 active protein	>1 publications with CCL25 and CCBP2

Diseases associated with CCL25 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>60 publications with CCL25 and Inflammation
Gastrointestinal Diseases Antibodies	>37 publications with CCL25 and Gastrointestinal Diseases
Immune System Diseases Antibodies	>29 publications with CCL25 and Immune System Diseases
Necrosis Antibodies	>24 publications with CCL25 and Necrosis
Lymphoma Antibodies	>7 publications with CCL25 and Lymphoma
Lung Diseases Antibodies	>7 publications with CCL25 and Lung Diseases
Neoplasms, Experimental Antibodies	>4 publications with CCL25 and Neoplasms, Experimental
Vascular Diseases Antibodies	>4 publications with CCL25 and Vascular Diseases
Breast Neoplasms Antibodies	>3 publications with CCL25 and Breast Neoplasms
Graft vs Host Disease Antibodies	>3 publications with CCL25 and Graft vs Host Disease

Organs/Tissues associated with CCL25 active protein

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>85 publications with CCL25 and Thymus
Lung Antibodies	>11 publications with CCL25 and Lung
Stomach Antibodies	>5 publications with CCL25 and Stomach
Mixed Antibodies	>3 publications with CCL25 and Mixed
Testis Antibodies	>1 publications with CCL25 and Testis