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KLRG1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844766

Background: KLRG1 belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and… More details

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Product Overview

Product Name
KLRG1, Recombinant Protein
Full Product Name
KLRG1, human recombinant
Product Gene Name
Product Synonym Names
Killer cell lectin-like receptor subfamily G member 1; 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE
Sequence
MGSSHHHHHH SSGLVPRGSH MGSLCQGSNY STCASCPSCP DRWMKYGNHC YYFSVEEKDW NSSLEFCLAR DSHLLVITDN QEMSLLQVFL SEAFCWIGLR NNSGWRWEDG SPLNFSRISS NSFVQTCGAI NKNGLQASSC EVPLHWVCKK VRL
Host
E Coli
Form/Format
0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Appearance: Liquid
Purity/Purification
>=85%
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -80 degree C
Shelf Life: 12 months
Molecular Weight
17 kDa (153 aa, 60-189 aa + His Tag), confirmed by MALDI-TOF.
OMIM
604874
3D Structure
ModBase 3D Structure for Q96E93
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for KLRG1 recombinant protein
SDS-PAGE

Other Notes

Small volumes of KLRG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLRG1 purchase

MBS844766 is a recombinant protein targeting KLRG1. Also known as KLRG1, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRG1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
killer cell lectin-like receptor subfamily G member 1
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily G, member 1
NCBI Official Symbol
KLRG1
NCBI Official Synonym Symbols
2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE
UniProt Protein Name
Killer cell lectin-like receptor subfamily G member 1
UniProt Synonym Protein Names
C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen
UniProt Gene Name
KLRG1
UniProt Synonym Gene Names
CLEC15A; MAFA; MAFAL
UniProt Entry Name
KLRG1_HUMAN
NCBI Protein Information
killer cell lectin-like receptor subfamily G member 1

NCBI Summary for KLRG1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for KLRG1

KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: plasma membrane; integral to membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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