PPA1 Active Protein

Name: PPA1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844780
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844780

Background: PPA1 (Pyrophosphatase) belongs to the PPase family. This protein is an enzyme that catalyzes the conversion of one molecule of pyrophosphate to two phosphate ions. The hydrolysis of inorganic pyrophosphate (PPi) to two phosphate ions is utilized… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PPA1, Active Protein

Full Product Name

PPA1, human recombinant

Product Gene Name

PPA1 active protein

Product Synonym Names

Inorganic pyrophosphatase; IOPPP; PP; PP1; SID6-8061

Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMSGFST EERAAPFSLE YRVFLKNEKG QYISPFHDIP IYADKDVFHM VVEVPRWSNA KMEIATKDPL NPIKQDVKKG KLRYVANLFP YKGYIWNYGA IPQTWEDPGH NDKHTGCCGD NDPIDVCEIG SKVCARGEII GVKVLGILAM IDEGETDWKV IAINVDDPDA ANYNDINDVK RLKPGYLEAT VDWFRRYKVP DGKPENEFAF NAEFKDKDFA IDIIKSTHDH WKALVTKKTN GKGISCMNTT LSESPFKCDP DAARAIVDAL PPPCESACTV PTDVDKWFHH QKN

Host

E Coli

Form/Format

0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 200 mM NaCl and 2 mM DTT
Appearance: Liquid

Purity/Purification

>=95%

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

35.2 kDa (313 aa, 1-289 aa + His Tag)

OMIM

179030

3D Structure

ModBase 3D Structure for Q15181

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is >28,000 pmoles/min/ug, and measured by its ability to hydrolyze pyrophosphate per minute at pH 9.0 at 25 degree C

Results

Specific activity is >28,000 pmoles/min/ug

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PPA1 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for PPA1 active protein

SDS-PAGE

Other Notes

Small volumes of PPA1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPA1 purchase

MBS844780 is an active protein targeting PPA1. Also known as PPA1, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPA1. It may not necessarily be applicable to this product.

NCBI GI #

11056044

NCBI GeneID

5464

NCBI Accession #

NP_066952.1

UniProt Primary Accession #

Q15181

UniProt Secondary Accession #

Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1

UniProt Related Accession #

Q15181

GenBank Nucleotide #

NM_021129.3

NCBI Official Full Name

inorganic pyrophosphatase

NCBI Official Synonym Full Names

pyrophosphatase (inorganic) 1

NCBI Official Symbol

PPA1

NCBI Official Synonym Symbols

PP; PP1; IOPPP; HEL-S-66p; SID6-8061

UniProt Protein Name

Inorganic pyrophosphatase

UniProt Synonym Protein Names

Pyrophosphate phospho-hydrolase; PPase

Protein Family

Minor serine/threonine-protein phosphatase

UniProt Gene Name

PPA1

UniProt Synonym Gene Names

IOPPP; PP; PPase

UniProt Entry Name

IPYR_HUMAN

NCBI Protein Information

inorganic pyrophosphatase

NCBI Summary for PPA1

The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

UniProt Comments for PPA1

PPA1: is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; Motility/polarity/chemotaxis; EC 3.6.1.1

Chromosomal Location of Human Ortholog: 10q11.1-q24

Cellular Component: cytoplasm; cytosol

Molecular Function: inorganic diphosphatase activity; magnesium ion binding

Biological Process: tRNA aminoacylation for protein translation; gene expression; phosphate metabolic process

Research Articles on PPA1

1. Results identify PP1 as a novel regulator of Cl(-)-HCO3(-) anion exchangers activity which, in concert with CFTR, coordinates events at both apical and basolateral membranes, crucial for efficient HCO3(-) secretion from Calu-3 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPA1 active protein

Reference Product	PubMed Publications
ATP5G2 active protein	>1 publications with PPA1 and ATP5G2

Diseases associated with PPA1 active protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>2 publications with PPA1 and Adenocarcinoma
Carcinoma Antibodies	>2 publications with PPA1 and Carcinoma
Liver Diseases Antibodies	>1 publications with PPA1 and Liver Diseases
Lung Diseases Antibodies	>1 publications with PPA1 and Lung Diseases
Neoplasms, Experimental Antibodies	>1 publications with PPA1 and Neoplasms, Experimental
Neurobehavioral Manifestations Antibodies	>1 publications with PPA1 and Neurobehavioral Manifestations
Liver Neoplasms Antibodies	>1 publications with PPA1 and Liver Neoplasms
Disease Models, Animal Antibodies	>1 publications with PPA1 and Disease Models, Animal
Liver Neoplasms, Experimental Antibodies	>1 publications with PPA1 and Liver Neoplasms, Experimental
Necrosis Antibodies	>1 publications with PPA1 and Necrosis

Organs/Tissues associated with PPA1 active protein

Organ/Tissue Name	Pubmed Publications
Ganglia Antibodies	>5 publications with PPA1 and Ganglia
Brain Antibodies	>5 publications with PPA1 and Brain
Blood Antibodies	>3 publications with PPA1 and Blood
Lung Antibodies	>2 publications with PPA1 and Lung
Lymph Node Antibodies	>1 publications with PPA1 and Lymph Node
Liver Antibodies	>1 publications with PPA1 and Liver
Thyroid Antibodies	>1 publications with PPA1 and Thyroid
Nerve Antibodies	>1 publications with PPA1 and Nerve
Bone Antibodies	>1 publications with PPA1 and Bone
Vascular Antibodies	>1 publications with PPA1 and Vascular