Prolactin Receptor (PRLR) Active Protein

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: cell surface; integral to membrane; extracellular region; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; metal ion binding; peptide hormone binding; ornithine decarboxylase activator activity; prolactin receptor activity

Biological Process: regulation of cell adhesion; lactation; transmembrane receptor protein tyrosine kinase activation (dimerization); cell surface receptor linked signal transduction; T cell activation; regulation of epithelial cell differentiation; tyrosine phosphorylation of JAK2 protein; steroid biosynthetic process; embryo implantation; negative regulation of apoptosis

Disease: Multiple Fibroadenomas Of The Breast; Hyperprolactinemia