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KLRK1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844807

Background: KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
KLRK1, Recombinant Protein
Full Product Name
KLRK1, human recombinant
Product Gene Name
KLRK1 recombinant protein
Product Synonym Names
NKG2-D type II integral membrane protein; CD314; D12S2489E; KLR; NKG2-D; NKG2D
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV
Host
E Coli
Form/Format
0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Appearance: Liquid
Purity/Purification
>=90%
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -80 degree C
Shelf Life: 12 months
Molecular Weight
19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.
OMIM
611817
3D Structure
ModBase 3D Structure for P26718
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for KLRK1 recombinant protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and Enzymes (A-Z)
Applications Tested/Suitable for KLRK1 recombinant protein
SDS-PAGE

Testing Data of KLRK1 recombinant protein

KLRK1 Recombinant Protein – Cat# MBS844807

Other Notes

Small volumes of KLRK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLRK1 purchase

MBS844807 is a recombinant protein targeting KLRK1. Also known as KLRK1, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRK1. It may not necessarily be applicable to this product.

NCBI GI #
315221164
NCBI GeneID
100528032
NCBI Accession #
NP_001186734.1
UniProt Primary Accession #
P26718
UniProt Secondary Accession #
Q9NR41; A8K7K5; A8K7P4
UniProt Related Accession #
P26718
GenBank Nucleotide #
NM_001199805.1
NCBI Official Full Name
NKG2-D type II integral membrane protein
NCBI Official Synonym Full Names
KLRC4-KLRK1 readthrough
NCBI Official Symbol
KLRC4-KLRK1
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD_antigen: CD314
Protein Family
NKG2-D type II integral membrane protein
UniProt Gene Name
KLRK1
UniProt Synonym Gene Names
D12S2489E; NKG2D
UniProt Entry Name
NKG2D_HUMAN
NCBI Protein Information
NKG2-D type II integral membrane protein

NCBI Summary for KLRK1

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]
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UniProt Comments for KLRK1

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; signal transduction; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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