Il-13 (IL13) Active Protein

Name: IL13 Active Protein; Il-13; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844821
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844821

Background: IL-13 is a immunoregulatory protein produced by activated T lymphocytes. The biological activities of IL-13 include the stimulation of B cell proliferation and immunoglobulin production. Recombinant murine IL-13 is a 12.3 kDa protein containing… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-13 (IL13), Active Protein

Full Product Name

IL-13, murine recombinant

Product Gene Name

IL13 active protein

Product Synonym Names

NC30; ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789.

Host

E Coli

Form/Format

Sterile filtered and lyophilized from 10 mM Sodium Citrate, pH 4.0
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

12.3 kDa

3D Structure

ModBase 3D Structure for P20109

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 ug/ul (Note: Slow to dissolve). The solution can be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? as determined by the dose-dependent stimulation of the proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 10? units/mg.

Results

< 4.0 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL13 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13 purchase

MBS844821 is an active protein targeting IL13. Also known as IL-13, murine recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #

6680403

NCBI GeneID

16163

NCBI Accession #

NP_032381.1

UniProt Primary Accession #

P20109

UniProt Related Accession #

P20109

GenBank Nucleotide #

NM_008355.3

NCBI Official Full Name

interleukin-13

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

Il13

NCBI Official Synonym Symbols

Il-13

UniProt Protein Name

Interleukin-13

UniProt Synonym Protein Names

T-cell activation protein P600

Protein Family

Interleukin

UniProt Gene Name

Il13

UniProt Synonym Gene Names

Il-13; IL-13

UniProt Entry Name

IL13_MOUSE

NCBI Protein Information

interleukin-13

UniProt Comments for IL13

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: interleukin-13 receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; positive regulation of mast cell degranulation; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; positive regulation of protein secretion; positive regulation of B cell proliferation; immune response; positive regulation of ion transport; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of NAD(P)H oxidase activity; positive regulation of macrophage activation

Research Articles on IL13

1. Inflammation induced genotoxicity found in asthma extends beyond the primary site of the lung to circulating leukocytes and erythroblasts in the bone marrow eliciting systemic effects driven by IL-13 over-expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.