LAG3 Recombinant Protein – Cat# MBS844823

LAG3/CD223 (LAG3) Recombinant Protein

Name: LAG3 Recombinant Protein; LAG3/CD223; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844823
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844823

Background: Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LAG3/CD223, Recombinant Protein

Full Product Name

Human CellExpLAG3 / CD223, human recombinant

Product Gene Name

LAG3 recombinant protein

Product Synonym Names

LAG3; CD223; FDC

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 47 kDa. The predicted N-terminus is Leu 23. DTT-reduced Protein migrates as 60 kDa due to glycosylation.

OMIM

153337

3D Structure

ModBase 3D Structure for P18627

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for LAG3 recombinant protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Proteins and E

Applications Tested/Suitable for LAG3 recombinant protein

SDS-PAGE

Other Notes

Small volumes of LAG3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAG3 purchase

MBS844823 is a recombinant protein targeting LAG3. Also known as Human CellExpLAG3 / CD223, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for LAG3. It may not necessarily be applicable to this product.

NCBI GI #

167614500

NCBI GeneID

3902

NCBI Accession #

NP_002277.4

UniProt Primary Accession #

P18627

UniProt Secondary Accession #

Q7Z643; A8K7T9

UniProt Related Accession #

P18627

GenBank Nucleotide #

NM_002286.5

NCBI Official Full Name

lymphocyte activation gene 3 protein

NCBI Official Synonym Full Names

lymphocyte-activation gene 3

NCBI Official Symbol

LAG3

NCBI Official Synonym Symbols

CD223

UniProt Protein Name

Lymphocyte activation gene 3 protein

UniProt Synonym Protein Names

Protein FDC; CD_antigen: CD223

Protein Family

Lymphocyte activation gene 3 protein

UniProt Gene Name

LAG3

UniProt Synonym Gene Names

FDC; LAG-3

UniProt Entry Name

LAG3_HUMAN

NCBI Protein Information

lymphocyte activation gene 3 protein

NCBI Summary for LAG3

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

UniProt Comments for LAG3

LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.32

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: transmembrane receptor activity; antigen binding; MHC class II protein binding

Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation

Research Articles on LAG3

1. The elevated expression of LAG-3 at the genital tract suggests it may regulate T-cell activation, and identify cells susceptible to HIV infection. The enrichment of LAG-3 on double negative T cells suggests LAG-3 may contribute to the immunoregulatory activity of these cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.