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NAD Kinase (NADK) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844828

Background: NAD kinase catalyzes the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP+ is an essential coenzyme in metabolism and provides reducing power to… More details

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Product Overview

Product Name
NAD Kinase (NADK), Active Protein
Full Product Name
NAD Kinase, human recombinant
Product Gene Name
NADK active protein
Product Synonym Names
NADK; Poly (P)/ATP NAD Kinase; EC 2.7.1.23.
Host
E Coli
Form/Format
1 mg/ml of ammonium sulphate suspension.
Appearance: Liquid
Purity/Purification
>=95%
Concentration
1 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 6 months
Molecular Weight
~50 kDa (monomer). Human full length NAD kinase (aa 1-446) is fused at the N-terminus to a His-tag.
OMIM
611616
3D Structure
ModBase 3D Structure for O95544
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
>= 1U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 umol of NADP per min.
Results
>= 1U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 umol of NADP per min.
Unit Definition
One unit is defined as the amount of enzyme that synthesizes 1 umol of NADP per min.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for NADK active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Other Proteins & EnzymesDiabetes; Obesity & Metabolic Syndrome; Lipids Metabolism; Proteins/Enzymes; Other (NEW)
Applications Tested/Suitable for NADK active protein
SDS-PAGE

Other Notes

Small volumes of NADK active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NADK purchase

MBS844828 is an active protein targeting NADK. Also known as NAD Kinase, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NADK. It may not necessarily be applicable to this product.

NCBI GI #
312222779
NCBI GeneID
65220
NCBI Accession #
NP_001185922.1
UniProt Primary Accession #
O95544
UniProt Secondary Accession #
Q5QPS4; Q9H2P2; Q9H931; A6NNN3; A8K296; B7Z434; F5GXR5
UniProt Related Accession #
O95544
GenBank Nucleotide #
NM_001198993.1
NCBI Official Full Name
NAD kinase isoform 1
NCBI Official Synonym Full Names
NAD kinase
NCBI Official Symbol
NADK
NCBI Official Synonym Symbols
dJ283E3.1
UniProt Protein Name
NAD kinase
UniProt Synonym Protein Names
Poly(P)/ATP NAD kinase
Protein Family
NAD kinase
UniProt Gene Name
NADK
UniProt Entry Name
NADK_HUMAN
NCBI Protein Information
NAD kinase

NCBI Summary for NADK

NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

UniProt Comments for NADK

NADK: Belongs to the NAD kinase family

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Kinase, other; EC 2.7.1.23

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: cytosol

Molecular Function: metal ion binding; ATP binding; NAD+ kinase activity

Biological Process: ATP metabolic process; vitamin metabolic process; NAD metabolic process; NADP biosynthetic process; phosphorylation; water-soluble vitamin metabolic process
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Research Articles on NADK

1. Using purified human NAD kinase, we revealed a sigmoidal kinetic behavior toward ATP and the inhibitory effects of NADPH and NADH

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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