Human Recombinant FKBP1B Active Protein – Cat# MBS844850

FKBP1B Human Recombinant Active Protein

Name: FKBP1B Active Protein; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS844850
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844850

Background: Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FKBP1B, Active Protein

Full Product Name

Human Recombinant FKBP1B

Product Gene Name

FKBP1B active protein

Product Synonym Names

Peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase; Human Recombinant FKBP1B

Sequence

MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE

Host

E Coli

Form/Format

0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.
Appearance: Liquid

Purity/Purification

>=90%

Concentration

0.25 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

14.2 kDa

OMIM

600620

3D Structure

ModBase 3D Structure for P68106

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 300 nmoles/min/mg

Unit Definition

Specific activity is defined as the amount of enzyme that cleaves 1 umole of suc-AAFP-pNA per minute at 25 degree C in Tris HCl pH 8.0 using chymotrypsin.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for FKBP1B active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for FKBP1B active protein

SDS-PAGE

Other Notes

Small volumes of FKBP1B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP1B purchase

MBS844850 is an active protein targeting FKBP1B. Also known as Human Recombinant FKBP1B. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP1B. It may not necessarily be applicable to this product.

NCBI GI #

4758380

NCBI GeneID

2281

NCBI Accession #

NP_004107.1

UniProt Primary Accession #

P68106

UniProt Secondary Accession #

Q13664; Q16645; Q53TM2; Q9BQ40

UniProt Related Accession #

P68106

GenBank Nucleotide #

NM_004116.3

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP1B isoform a

NCBI Official Synonym Full Names

FK506 binding protein 1B, 12.6 kDa

NCBI Official Symbol

FKBP1B

NCBI Official Synonym Symbols

OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP1B

UniProt Synonym Protein Names

12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

FKBP1B

UniProt Synonym Gene Names

FKBP12.6; FKBP1L; FKBP9; OTK4; PPIase FKBP1B; 12.6 kDa FKBP; FKBP-12.6; FKBP-1B

UniProt Entry Name

FKB1B_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP1B

NCBI Summary for FKBP1B

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for FKBP1B

FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: sarcoplasmic reticulum membrane; membrane; cytoplasm; Z disc; cytosol

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; cyclic nucleotide binding; calcium channel inhibitor activity; ryanodine-sensitive calcium-release channel activity; receptor binding

Biological Process: positive regulation of sequestering of calcium ion; positive regulation of axon regeneration; protein maturation via protein folding; negative regulation of heart rate; cytosolic calcium ion homeostasis; protein peptidyl-prolyl isomerization; response to redox state; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; T cell proliferation; negative regulation of protein phosphatase type 2B activity; response to vitamin E; smooth muscle contraction; 'de novo' protein folding; response to hydrogen peroxide; insulin secretion; negative regulation of release of sequestered calcium ion into cytosol; action potential propagation; response to glucose stimulus; protein refolding; transmembrane transport

Research Articles on FKBP1B

1. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.