Human IGFBP1 Active Protein – Cat# MBS142176

Insulin Like Growth Factor Binding Protein-1 (IGFBP1) Human Active Protein

Name: IGFBP1 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142176
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142176

Description: IGFBP-1 Human Recombinant (26-259 a.a.) produced in NS0 is a single, glycosylated, polypeptide chain containing 234 amino acids and having a molecular mass of 25kDa. The IGFBP1 is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Insulin Like Growth Factor Binding Protein-1 (IGFBP1), Active Protein

Full Product Name

Human Insulin Like Growth Factor Binding Protein-1

Product Gene Name

IGFBP1 active protein

Product Synonym Names

IGFBP 1 Human; Insulin-Like Growth Factor Binding Protein-1 Human; IBP-1; IGF-Binding Protein 1; AFBP; PP12; IGF-BP25; hIGFBP-1; IGFBP-1

Sequence

APWQCAPCSA EKLALCPPVS ASCSEVTRSA GCGCCPMCAL PLGAACGVAT ARCARGLSCR ALPGEQQPLH ALTRGQGACV QESDASAPHA AEAGSPESPE STEITEEELL DNFHLMAPSE EDHSILWDAI STYDGSKALH VTNIKKWKEP CRIELYRVVE SLAKAQETSG EEISKFYLPN CNKNGFYHSR QCETSMDGEA GLCWCVYPWN GKRIPGSPEI RGDPNCQIYF NVQN

Host

Mouse myeloma cell line NS0

Form/Format

IGFBP-1 protein was lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized IGFBP1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGF-BP1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

27,904 Da

OMIM

146730

3D Structure

ModBase 3D Structure for P08833

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IGFBP1 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50 as determined by the inhibition of rHuIGF-I-induced proliferation of human MCF-7 cells, is less than 4ug/ml.

Product Categories/Family for IGFBP1 active protein

Cytokines and Growth Factors; Growth Factors; IGFBP

Other Notes

Small volumes of IGFBP1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGFBP1 purchase

MBS142176 is an active protein targeting IGFBP1. Also known as Human Insulin Like Growth Factor Binding Protein-1. Host: Mouse myeloma cell line NS0.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP1. It may not necessarily be applicable to this product.

NCBI GI #

4504615

NCBI GeneID

3484

NCBI Accession #

NP_000587.1

UniProt Primary Accession #

P08833

UniProt Secondary Accession #

Q8IYP5; A4D2F4; D3DVL9

UniProt Related Accession #

P08833

GenBank Nucleotide #

NM_000596.2

NCBI Official Full Name

insulin-like growth factor-binding protein 1

NCBI Official Synonym Full Names

insulin-like growth factor binding protein 1

NCBI Official Symbol

IGFBP1

NCBI Official Synonym Symbols

AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1

UniProt Protein Name

Insulin-like growth factor-binding protein 1

UniProt Synonym Protein Names

Placental protein 12; PP12

Protein Family

Insulin-like growth factor-binding protein

UniProt Gene Name

IGFBP1

UniProt Synonym Gene Names

IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

UniProt Entry Name

IBP1_HUMAN

NCBI Protein Information

insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; placental protein 12

NCBI Summary for IGFBP1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

UniProt Comments for IGFBP1

IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: regulation of insulin-like growth factor receptor signaling pathway; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; tissue regeneration; unfolded protein response; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth

Research Articles on IGFBP1

1. In the second trimester, rapid cervical phIGFBP-1 testing in asymptomatic twin pregnancies has a poor performance in predicting spontaneous preterm delivery

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IGFBP1 active protein

Reference Product	PubMed Publications
IGFBP4 active protein	>146 publications with IGFBP1 and IGFBP4
IGF1 active protein	>72 publications with IGFBP1 and IGF1
IGF2 active protein	>33 publications with IGFBP1 and IGF2
IL6 active protein	>10 publications with IGFBP1 and IL6
FOXA2 active protein	>8 publications with IGFBP1 and FOXA2
INS active protein	>6 publications with IGFBP1 and INS
ATF4 active protein	>3 publications with IGFBP1 and ATF4
HIF1A active protein	>3 publications with IGFBP1 and HIF1A
NR3C1 active protein	>1 publications with IGFBP1 and NR3C1

Pathways associated with IGFBP1 active protein

Products by Pathway	Pathway Diagram
ATF4 Activates Genes Pathway antibodies	ATF4 Activates Genes Pathway Diagram
AhR Pathway antibodies	AhR Pathway Diagram
FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies	FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
HIF-1-alpha Transcription Factor Network Pathway antibodies	HIF-1-alpha Transcription Factor Network Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
PERK Regulates Gene Expression Pathway antibodies	PERK Regulates Gene Expression Pathway Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Unfolded Protein Response (UPR) Pathway antibodies	Unfolded Protein Response (UPR) Pathway Diagram

Diseases associated with IGFBP1 active protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>131 publications with IGFBP1 and Liver Diseases
Cardiovascular Diseases Antibodies	>124 publications with IGFBP1 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>91 publications with IGFBP1 and Disease Models, Animal
Breast Neoplasms Antibodies	>86 publications with IGFBP1 and Breast Neoplasms
Kidney Diseases Antibodies	>83 publications with IGFBP1 and Kidney Diseases
Liver Neoplasms Antibodies	>81 publications with IGFBP1 and Liver Neoplasms
Adenocarcinoma Antibodies	>80 publications with IGFBP1 and Adenocarcinoma
Brain Diseases Antibodies	>76 publications with IGFBP1 and Brain Diseases
Necrosis Antibodies	>65 publications with IGFBP1 and Necrosis
Inflammation Antibodies	>63 publications with IGFBP1 and Inflammation

Organs/Tissues associated with IGFBP1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1333 publications with IGFBP1 and Blood
Liver Antibodies	>453 publications with IGFBP1 and Liver
Uterus Antibodies	>330 publications with IGFBP1 and Uterus
Placenta Antibodies	>241 publications with IGFBP1 and Placenta
Embryonic Tissue Antibodies	>132 publications with IGFBP1 and Embryonic Tissue
Bone Antibodies	>98 publications with IGFBP1 and Bone
Brain Antibodies	>87 publications with IGFBP1 and Brain
Lung Antibodies	>46 publications with IGFBP1 and Lung
Skin Antibodies	>32 publications with IGFBP1 and Skin
Pancreas Antibodies	>31 publications with IGFBP1 and Pancreas