Human Cellexp IFNL3 Active Protein – Cat# MBS844909

Il-28b (IFNL3) Human Cellexp Active Protein

Name: IFNL3 Active Protein; Il-28b; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844909
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844909

Background: IL-28B is a cytokine remotely related to type I interferons and the IL-10 family. Interleukin-28B, interleukin 28A (IL28A), and interleukin 29 (IL29) are 3 closely related cytokine genes which form a cytokine gene cluster on a chromosomal region… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-28B (IFNL3), Active Protein

Full Product Name

Human CellExp IL-28B, Human Recombinant

Product Gene Name

IFNL3 active protein

Product Synonym Names

Interleukin-28A; IL-28A; IFN-Lambda 2; Interferon-Lambda 2; Cytokine ZCYTO20; IL28A; IFNL2; ZCYTO20.; Human Cellexp Human Recombinant IL-28B

Host

Human 293 cell expressed

Form/Format

Lyophilized in PBS.
Appearance: Lyophilized

Purity/Purification

> 95%

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

24 kDa, monomer, non-glycosylated

OMIM

607402

3D Structure

ModBase 3D Structure for Q8IZI9

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Endotoxin Level

< 1.0 EU per 1 mug of protein

Biological Activity

ED?? is typically 0.1 to 1 ng/mL. The specific activity was determined by the dose-dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus.

Results

0.1 to 1 ng/ml

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for IFNL3 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; InterleukinsCytokines; Growth Factors & Hormones; Cytokines & Growth Fact

Applications Tested/Suitable for IFNL3 active protein

SDS-PAGE

Other Notes

Small volumes of IFNL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNL3 purchase

MBS844909 is an active protein targeting IFNL3. Also known as Human CellExp IL-28B, Human Recombinant. Host: Human 293 cell expressed.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNL3. It may not necessarily be applicable to this product.

NCBI GI #

28144901

NCBI GeneID

282617

NCBI Accession #

NP_742151.2

UniProt Primary Accession #

Q8IZI9

UniProt Secondary Accession #

Q6VN56; Q7Z4J3; Q8IWL6; A2BDE1

UniProt Related Accession #

Q8IZI9

GenBank Nucleotide #

NM_172139.2

NCBI Official Full Name

interferon lambda-3

NCBI Official Synonym Full Names

interferon, lambda 3

NCBI Official Symbol

IFNL3

NCBI Official Synonym Symbols

IL28B; IL28C; IL-28B

UniProt Protein Name

Interferon lambda-3

UniProt Synonym Protein Names

Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C

Protein Family

Interferon

UniProt Gene Name

IFNL3

UniProt Synonym Gene Names

IL28B; IL28C; ZCYTO22; IFN-lambda-3; IL-28B; IL-28C

UniProt Entry Name

IFNL3_HUMAN

NCBI Protein Information

interferon lambda-3

NCBI Summary for IFNL3

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

UniProt Comments for IFNL3

IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus

Disease: Hepatitis C Virus, Susceptibility To

Research Articles on IFNL3

1. This study indicates that IFNL3 CC genotype predicts higher hepatitis C virus RNA levels in early acute hepatitis C virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.