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Visfatin (NAMPT) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844921

Background: Visfatin also called Pre-B Cell Colony Enhancing Factor, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF More details

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Testing Data View PDF
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Product Overview

Product Name
Visfatin (NAMPT), Active Protein
Full Product Name
Visfatin, rat recombinant
Product Gene Name
NAMPT active protein
Product Synonym Names
Nicotinamide phosphoribosyltransferase; Pre-B-cell colony-enhancing factor 1 homolog; NAmPRTase; Nampt; PBEF
Host
E Coli
Form/Format
Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
53.0 kDa
3D Structure
ModBase 3D Structure for Q80Z29
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in PBS to the concentration of 0.1-1 mg/ml.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Mimics insulin effects in differentiating 3T3-L1 cells.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for NAMPT active protein

Cytokines; Growth Factors & Hormones; VisfatinsCytokines; Growth Factors & Hormones; AdipokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Visfatins (NEW) Proteins and
Applications Tested/Suitable for NAMPT active protein
SDS-PAGE; HPLC

Testing Data of NAMPT active protein

NAMPT Active Protein – Cat# MBS844921

Other Notes

Small volumes of NAMPT active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NAMPT purchase

MBS844921 is an active protein targeting NAMPT. Also known as Visfatin, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NAMPT. It may not necessarily be applicable to this product.

NCBI GI #
29293813
NCBI GeneID
297508
NCBI Accession #
NP_808789.1
UniProt Primary Accession #
Q80Z29
UniProt Secondary Accession #
Q2VT47
UniProt Related Accession #
Q80Z29
GenBank Nucleotide #
NM_177928.3
NCBI Official Full Name
nicotinamide phosphoribosyltransferase
NCBI Official Synonym Full Names
nicotinamide phosphoribosyltransferase
NCBI Official Symbol
Nampt
NCBI Official Synonym Symbols
Pbef; Pbef1
UniProt Protein Name
Nicotinamide phosphoribosyltransferase
UniProt Synonym Protein Names
Pre-B-cell colony-enhancing factor 1 homolog; PBEF; Visfatin
Protein Family
Nicotinamide phosphoribosyltransferase
UniProt Gene Name
Nampt
UniProt Synonym Gene Names
Pbef1; NAmPRTase; Nampt; PBEF
UniProt Entry Name
NAMPT_RAT
NCBI Protein Information
nicotinamide phosphoribosyltransferase

NCBI Summary for NAMPT

has similarity to cytokines but is not secreted; localized to the nucleus and cytoplasm, changes in subcellular localization may be associated with the cell cycle [RGD, Feb 2006]

UniProt Comments for NAMPT

PBEF: an ubiquitous protein originally described as a cytokine which acts on early B-lineage precursor cells. Other reports indicate that PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. Contains a catalytically active nicotinate phosphoribosyltransferase domain, an enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis.

Protein type: EC 2.4.2.12; Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; Cytokine

Cellular Component: extracellular space; cytoplasm; nucleus

Molecular Function: protein homodimerization activity; cytokine activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; drug binding; nicotinamide phosphoribosyltransferase activity

Biological Process: NAD biosynthetic process; positive regulation of smooth muscle cell proliferation; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; female pregnancy; circadian regulation of gene expression; response to organic cyclic substance; positive regulation of nitric-oxide synthase biosynthetic process
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Research Articles on NAMPT

1. Visfatin induced the expression of alphaSMA in cultureactivated rat HSC, which was accompanied by a significant increase in collagen types I and III.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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