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BLVRA Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844925

Background: BLVRA, also known as biliverdin reductase A, belongs to the gfo/idh/mocA family. This protein is an enzyme that converts biliverdin to bilirubin, converting a double-bond between the second and third pyrrole ring into a single-bond. (Bilirubin +… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
BLVRA, Active Protein
Full Product Name
BLVRA, human recombinant
Product Gene Name
BLVRA active protein
Product Synonym Names
Biliverdin reductase A; BLVR; BVR; BVRA
Sequence
MAEPERKFGV VVVGVGRAGS VRMRDLRNPH PSSAFLNLIG FVSRRELGSI DGVQQISLED ALSSQEVEVA YICSESSSHE DYIRQFLNAG KHVLVEYPMT LSLAAAQELW ELAEQKGKVL HEEHVELLME EFAFLKKEVV GKDLLKGSLL FTAGPLEEER FGFPAFSGIS RLTWLVSLFG ELSLVSATLE ERKEDQYMKM TVCLETEKKS PLSWIEEKGP GLKRNRYLSF HFKSGSLENV PNVGVNKNIF LKDQNIFVQK LLGQFSEKEL AAEKKRILHC LGLAEEIQKY CCSRK
Host
E Coli
Form/Format
1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Appearance: Liquid
Purity/Purification
>=90%
Concentration
1 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
33.3 kDa (295 aa, 3-296 aa)
OMIM
109750
3D Structure
ModBase 3D Structure for P53004
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 1.0 EU per 1 mug of protein (determined by LAL method)
Biological Activity
Specific activity is > 30 pmoles/min/ug. One unit BLVRA will transform 1.0 pmole of biliverdin to bilirubin per minute in an NADPH dependent reaction pH 8.0 at 25 degree C.
Results
Specific activity is > 30 pmoles/min/ug.
Unit Definition
One unit BLVRA will transform 1.0 pmole of biliverdin to bilirubin per minute in an NADPH dependent reaction pH 8.0 at 25 degree C.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for BLVRA active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)
Applications Tested/Suitable for BLVRA active protein
SDS-PAGE

Testing Data of BLVRA active protein

BLVRA Active Protein – Cat# MBS844925

Other Notes

Small volumes of BLVRA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLVRA purchase

MBS844925 is an active protein targeting BLVRA. Also known as BLVRA, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BLVRA. It may not necessarily be applicable to this product.

NCBI GI #
33589854
NCBI GeneID
644
NCBI Accession #
NP_000703.2
UniProt Primary Accession #
P53004
UniProt Secondary Accession #
O95019; Q86UX0; Q96QL4; Q9BRW8; A8K747
UniProt Related Accession #
P53004
GenBank Nucleotide #
NM_000712.3
NCBI Official Full Name
biliverdin reductase A
NCBI Official Synonym Full Names
biliverdin reductase A
NCBI Official Symbol
BLVRA
NCBI Official Synonym Symbols
BVR; BLVR; BVRA
UniProt Protein Name
Biliverdin reductase A
UniProt Synonym Protein Names
Biliverdin-IX alpha-reductase
Protein Family
Biliverdin reductase
UniProt Gene Name
BLVRA
UniProt Synonym Gene Names
BLVR; BVR; BVR A
UniProt Entry Name
BIEA_HUMAN
NCBI Protein Information
biliverdin reductase A

NCBI Summary for BLVRA

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for BLVRA

BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.

Protein type: Protein kinase, Ser/Thr (non-receptor); Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Kinase, protein; Oxidoreductase; EC 1.3.1.24; ATYPICAL group; BLVRA family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol

Molecular Function: zinc ion binding; biliverdin reductase activity

Biological Process: heme catabolic process; porphyrin metabolic process

Disease: Hyperbiliverdinemia
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Research Articles on BLVRA

1. Interactions of HO-2 with CPR and BVR, were evaluated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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