HIST1H4A Recombinant Protein – Cat# MBS844947

Histone H4 (HIST1H4A) Recombinant Protein

Name: HIST1H4A Recombinant Protein; Histone H4; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844947
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844947

Background: H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Histone H4 (HIST1H4A), Recombinant Protein

Full Product Name

Histone H4 (1-103 aa), Human recombinant

Product Gene Name

HIST1H4A recombinant protein

Product Synonym Names

Histone H4; H4; Histone H4 (1-103 aa); Human recombinant

Host

E Coli

Form/Format

Lyophilized powder. Recommended buffer is 50 mM NaPO? containing 100 mM sodium chloride and 20% glycerol.
Appearance: Lyophilized powder

Purity/Purification

>=95%

Preparation and Storage

At -80 degree C
Shelf Life: 6 months

Molecular Weight

11.5 kDa (1-136 aa)

Sequence Positions

1-103

OMIM

142750

3D Structure

ModBase 3D Structure for P62805

Solubility/Reconstitution Instructions

Resuspend in buffer of choice.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for HIST1H4A recombinant protein

Epigenetics; Histones; Recombinant ProteinsEpigenetics; Recombinant ProteinsProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for HIST1H4A recombinant protein

SDS-PAGE; HPLC

Other Notes

Small volumes of HIST1H4A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HIST1H4A purchase

MBS844947 is a recombinant protein targeting HIST1H4A. Also known as Histone H4 (1-103 aa), Human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HIST1H4A. It may not necessarily be applicable to this product.

NCBI GI #

77539758

NCBI GeneID

554313

NCBI Accession #

NP_001029249.1

UniProt Primary Accession #

P62805

UniProt Secondary Accession #

P02304; P02305; Q6DRA9; Q6FGB8; Q6NWP7; A2VCL0

UniProt Related Accession #

P62805

GenBank Nucleotide #

NM_001034077.4

NCBI Official Full Name

histone H4

NCBI Official Synonym Full Names

histone cluster 2, H4b

NCBI Official Symbol

HIST2H4B

NCBI Official Synonym Symbols

H4/o

UniProt Protein Name

Histone H4

Protein Family

Histone H4-like protein

UniProt Gene Name

HIST1H4A

UniProt Synonym Gene Names

H4/A; H4FA

UniProt Entry Name

H4_HUMAN

NCBI Protein Information

histone H4

NCBI Summary for HIST1H4A

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008]

UniProt Comments for HIST1H4A

H4: histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H4 is intronless.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleus

Molecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activity

Biological Process: chromatin silencing at rDNA; nucleosome assembly; establishment and/or maintenance of chromatin architecture; DNA replication-independent nucleosome assembly at centromere; DNA replication-independent nucleosome assembly; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; mitotic cell cycle; regulation of gene expression, epigenetic; DNA methylation on cytosine; telomere maintenance; DNA replication-dependent nucleosome assembly; negative regulation of megakaryocyte differentiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.