RSK Recombinant Protein – Cat# MBS844986

RSK1 (RSK) Recombinant Protein

Name: RSK Recombinant Protein; RSK1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844986
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844986

Background: The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk). RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

RSK1, Recombinant Protein

Full Product Name

RSK1, Active

Product Gene Name

RSK recombinant protein

Product Synonym Names

RSK; ribosomal s6 kinase (rsk); pp90RSK4

Host

Baculovirus (Sf9 insect cells)

Form/Format

Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Appearance: Liquid

Purity/Purification

>=90%

Concentration

5ug/50 ul (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

108.0 kDa

OMIM

601684

3D Structure

ModBase 3D Structure for Q15418

Activity (Specifications/test method)

38 nmol phosphate incorporated into S6K substrate peptide minute per mg protein at 30 degree C for 15 minutes using a final concentration of 50 uM ATP (0.83 uCi/assay).

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for RSK recombinant protein

SDS-PAGE; HPLC

Other Notes

Small volumes of RSK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RSK purchase

MBS844986 is a recombinant protein targeting RSK. Also known as RSK1, Active. Host: Baculovirus (Sf9 insect cells).

Additional Details

NCBI/Uniprot data below describe general gene information for RSK. It may not necessarily be applicable to this product.

NCBI GI #

55743134

NCBI GeneID

6195

NCBI Accession #

NP_001006666.1

UniProt Primary Accession #

Q15418

UniProt Secondary Accession #

Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2; A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4

UniProt Related Accession #

Q15418

GenBank Nucleotide #

NM_001006665.1

NCBI Official Full Name

ribosomal protein S6 kinase alpha-1 isoform b

NCBI Official Synonym Full Names

ribosomal protein S6 kinase, 90kDa, polypeptide 1

NCBI Official Symbol

RPS6KA1

NCBI Official Synonym Symbols

RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A

UniProt Protein Name

Ribosomal protein S6 kinase alpha-1

UniProt Synonym Protein Names

90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1

UniProt Gene Name

RPS6KA1

UniProt Synonym Gene Names

MAPKAPK1A; RSK1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1

UniProt Entry Name

KS6A1_HUMAN

NCBI Protein Information

ribosomal protein S6 kinase alpha-1

NCBI Summary for RSK

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for RSK

p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Translation; Kinase, protein; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 1p

Cellular Component: nucleoplasm; cytoplasm; spindle; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis

Research Articles on RSK

1. findings demonstrate that Yersinia enterocolitica rYopM interacts with RSK1 and PRK2 following cell-penetration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.