THIC Recombinant Protein – Cat# MBS844987

ACAT-2 (THIC) Recombinant Protein

Name: THIC Recombinant Protein; ACAT-2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844987
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844987

Background: Acetyl-Coenzyme A acetyltransferase 2 (ACAT2) is an enzyme involved in lipid metabolism. Patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows complementary overlapping with the 3 prime region of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ACAT-2 (THIC), Recombinant Protein

Full Product Name

ACAT-2, human recombinant

Product Gene Name

THIC recombinant protein

Product Synonym Names

Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2; Sterol O-acyltransferase 2; Acyl-coenzyme A:cholesterol acyltransferase 2; Cholesterol acyltransferase 2 ; Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2.

Host

E Coli

Form/Format

Sterile filtered solution (1 mg/ml) in 10 mM Tris, pH 8.0, 0.1% Triton X-100 and 0.002% NaN3.
Appearance: Lyophilized protein

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

41.3 kDa

OMIM

100678

3D Structure

ModBase 3D Structure for Q9BWD1

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for THIC recombinant protein

SDS-PAGE; HPLC

Other Notes

Small volumes of THIC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THIC purchase

MBS844987 is a recombinant protein targeting THIC. Also known as ACAT-2, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for THIC. It may not necessarily be applicable to this product.

NCBI GI #

735997436

NCBI GeneID

NCBI Accession #

NP_001290182.1

UniProt Primary Accession #

Q9BWD1

UniProt Secondary Accession #

Q16146; Q5TCL7; Q8TDM4; B7Z233; E1P5B1

UniProt Related Accession #

Q9BWD1

GenBank Nucleotide #

NM_001303253.1

NCBI Official Full Name

acetyl-CoA acetyltransferase, cytosolic isoform 2

NCBI Official Synonym Full Names

acetyl-CoA acetyltransferase 2

NCBI Official Symbol

ACAT2

UniProt Protein Name

Acetyl-CoA acetyltransferase, cytosolic

UniProt Synonym Protein Names

Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase

Protein Family

Phosphomethylpyrimidine synthase

UniProt Gene Name

ACAT2

UniProt Synonym Gene Names

ACTL

UniProt Entry Name

THIC_HUMAN

NCBI Protein Information

acetyl-CoA acetyltransferase, cytosolic

NCBI Summary for THIC

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

UniProt Comments for THIC

ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Carbohydrate Metabolism - butanoate; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - propanoate; Acetyltransferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.3.1.9

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency

Research Articles on THIC

1. Results show that DLAT and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.