Procathepsin K (CATK) Active Protein

Name: CATK Active Protein; Procathepsin K; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845004
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845004

Background: Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Procathepsin K (CATK), Active Protein

Full Product Name

Procathepsin K, rat recombinant

Product Gene Name

CATK active protein

Product Synonym Names

CTSK; CTSO; CTSO3

Host

E Coli

Form/Format

1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Appearance: Liquid

Purity/Purification

>=95%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

35.4 kDa

3D Structure

ModBase 3D Structure for P00786

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity (Specifications/test method)

>400 mU/mg

Biological Activity

The specific activity is >400 mU/mg (1U = 1 umole/min/mg) as measured by Cathepsin K Activity Assay Kit

Results

>400 mU/mg

Unit Definition

1 U = 1 umole/min/mg

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for CATK active protein

Apoptosis; Non-Caspase Proteases; Cathepsin; Cathepsin EnzymesProteins and Enzymes; Proteases; CathepsinsProteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & Enzyme

Applications Tested/Suitable for CATK active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of CATK active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CATK purchase

MBS845004 is an active protein targeting CATK. Also known as Procathepsin K, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CATK. It may not necessarily be applicable to this product.

NCBI GI #

6978721

NCBI GeneID

25425

NCBI Accession #

NP_037071.1

UniProt Primary Accession #

P00786

UniProt Related Accession #

P00786

GenBank Nucleotide #

NM_012939.1

NCBI Official Full Name

pro-cathepsin H

NCBI Official Synonym Full Names

cathepsin H

NCBI Official Symbol

Ctsh

UniProt Protein Name

Pro-cathepsin H

UniProt Gene Name

Ctsh

UniProt Entry Name

CATH_RAT

NCBI Protein Information

pro-cathepsin H

NCBI Summary for CATK

lysosomal protease that plays a role in protein metabolism [RGD, Feb 2006]

UniProt Comments for CATK

CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.

Protein type: Protease; Endoplasmic reticulum; EC 3.4.22.16

Cellular Component: extracellular space; lysosome; acrosome; axoneme; outer dense fiber; cytosol

Molecular Function: peptidase activity; protein self-association; HLA-A specific activating MHC class I receptor activity; cysteine-type endopeptidase activity; serine-type endopeptidase activity; endopeptidase activity; apoptotic protease activator activity; protein complex binding; caspase activator activity; kininogen binding; aminopeptidase activity; cysteine-type peptidase activity

Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; apoptosis; membrane protein proteolysis; proteolysis; positive regulation of angiogenesis; positive regulation of cell proliferation; spermatogenesis; zymogen activation; surfactant homeostasis; metanephros development; immune response-regulating signal transduction; negative regulation of apoptosis; positive regulation of cell migration; T cell mediated cytotoxicity

Research Articles on CATK

1. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CATK active protein

Products by Pathway	Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with CATK active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>24 publications with CATK and Nervous System Diseases
Inflammation Antibodies	>18 publications with CATK and Inflammation
Disease Models, Animal Antibodies	>18 publications with CATK and Disease Models, Animal
Neoplasms, Experimental Antibodies	>13 publications with CATK and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>9 publications with CATK and Cardiovascular Diseases
Adenocarcinoma Antibodies	>9 publications with CATK and Adenocarcinoma
Heart Diseases Antibodies	>8 publications with CATK and Heart Diseases
Lung Neoplasms Antibodies	>8 publications with CATK and Lung Neoplasms
Kidney Diseases Antibodies	>7 publications with CATK and Kidney Diseases
Necrosis Antibodies	>6 publications with CATK and Necrosis

Organs/Tissues associated with CATK active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>55 publications with CATK and Liver
Kidney Antibodies	>35 publications with CATK and Kidney
Lung Antibodies	>27 publications with CATK and Lung
Brain Antibodies	>24 publications with CATK and Brain
Spleen Antibodies	>14 publications with CATK and Spleen
Heart Antibodies	>12 publications with CATK and Heart
Ovary Antibodies	>6 publications with CATK and Ovary
Colon Antibodies	>6 publications with CATK and Colon
Pituitary Gland Antibodies	>6 publications with CATK and Pituitary Gland
Connective Tissue Antibodies	>5 publications with CATK and Connective Tissue