PEDF Active Protein

Name: PEDF Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845058
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845058

Background: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PEDF, Active Protein

Full Product Name

PEDF, human recombinant

Product Gene Name

PEDF active protein

Product Synonym Names

Pigment epithelium-derived factor; PEDF; Serpin-F1; SerpinF1; EPC-1; EPC1; PIG35

Host

E Coli

Form/Format

The sterile filtered concentrated (1 mg/ml) protein solution was lyophilized with 20 mM PBS & 150 mM NaCl pH-7.4.
Appearance: Lyophilized protein

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

44.5 kDa

OMIM

172860

3D Structure

ModBase 3D Structure for P36955

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

The sterile filtered concentrated (1 mg/ml) protein solution was lyophilized with 20 mM phosphate buffer & 150 mM NaCl pH-7.4.

Endotoxin Level

<0.1 ng/mug

Biological Activity

Not available at this time

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PEDF active protein

Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & Enzymes

Applications Tested/Suitable for PEDF active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of PEDF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PEDF purchase

MBS845058 is an active protein targeting PEDF. Also known as PEDF, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PEDF. It may not necessarily be applicable to this product.

NCBI GI #

39725934

NCBI GeneID

5176

NCBI Accession #

NP_002606.3

UniProt Primary Accession #

P36955

UniProt Secondary Accession #

Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4; F1T092

UniProt Related Accession #

P36955

GenBank Nucleotide #

NM_002615.5

NCBI Official Full Name

pigment epithelium-derived factor

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

NCBI Official Symbol

SERPINF1

NCBI Official Synonym Symbols

OI6; OI12; PEDF; EPC-1; PIG35

UniProt Protein Name

Pigment epithelium-derived factor

UniProt Synonym Protein Names

Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1

Protein Family

Pigment epithelium-derived factor

UniProt Gene Name

SERPINF1

UniProt Synonym Gene Names

PEDF; PEDF

UniProt Entry Name

PEDF_HUMAN

NCBI Protein Information

pigment epithelium-derived factor

NCBI Summary for PEDF

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

UniProt Comments for PEDF

PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; melanosome; extracellular region; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; negative regulation of angiogenesis; positive regulation of neurogenesis; ovulation cycle; retina development in camera-type eye; short-term memory; negative regulation of inflammatory response; multicellular organismal development; response to arsenic; response to acidity; kidney development; aging

Disease: Osteogenesis Imperfecta, Type Vi

Research Articles on PEDF

1. study supports the possible influence of sICAM-1 and PEDF on the pathophysiology of retinal neovascularization in SCD patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PEDF active protein

Reference Product	PubMed Publications
VEGFA active protein	>2 publications with PEDF and VEGFA

Diseases associated with PEDF active protein

Disease Name	Pubmed Publications
Nerve Degeneration Antibodies	>1 publications with PEDF and Nerve Degeneration
Brain Diseases Antibodies	>1 publications with PEDF and Brain Diseases
Urinary Bladder Neoplasms Antibodies	>1 publications with PEDF and Urinary Bladder Neoplasms
Proteinuria Antibodies	>1 publications with PEDF and Proteinuria
Lung Neoplasms Antibodies	>1 publications with PEDF and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with PEDF and Cell Transformation, Neoplastic
Weight Loss Antibodies	>1 publications with PEDF and Weight Loss

Organs/Tissues associated with PEDF active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>24 publications with PEDF and Bone
Nerve Antibodies	>23 publications with PEDF and Nerve
Eye Antibodies	>21 publications with PEDF and Eye
Connective Tissue Antibodies	>10 publications with PEDF and Connective Tissue
Skin Antibodies	>7 publications with PEDF and Skin
Blood Antibodies	>7 publications with PEDF and Blood
Adipose Tissue Antibodies	>5 publications with PEDF and Adipose Tissue
Brain Antibodies	>5 publications with PEDF and Brain
Embryonic Tissue Antibodies	>3 publications with PEDF and Embryonic Tissue
Heart Antibodies	>2 publications with PEDF and Heart