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Eotaxin/CCL11 (CCL11, SCYA11) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845065

Background: Murine eotaxin shares many of the biological and physical characteristics of human eotaxin. The chemokine exhibits a high chemotactic selectivity for eosinophils and belongs to the C-C family of chemokines, along with chemokines such as RANTES,… More details

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Product Overview

Product Name
Eotaxin/CCL11 (Ccl11, Scya11), Active Protein
Full Product Name
Eotaxin / CCL11, murine recombinant
Product Gene Name
Ccl11, Scya11 active protein
Product Synonym Names
Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11; Murine Eotaxin
Host
E Coli
Form/Format
Sterile filtered and then lyophilized with no additives. The protein may appear as a haze or film that is difficult to see at the bottom of the vial.
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
8.4 kDa
3D Structure
ModBase 3D Structure for P48298
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1 ug/ul. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
Endotoxin Level
<0.1 ng/mug
Biological Activity
The recombinant murine eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 100 to 1000 ng/ml.
Results
100-1000 ng/ml
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for Ccl11, Scya11 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for Ccl11, Scya11 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of Ccl11, Scya11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ccl11, Scya11 purchase

MBS845065 is an active protein targeting Ccl11, Scya11. Also known as Eotaxin / CCL11, murine recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccl11, Scya11. It may not necessarily be applicable to this product.

NCBI GI #
6755418
NCBI GeneID
20292
NCBI Accession #
NP_035460.1
UniProt Primary Accession #
P48298
UniProt Related Accession #
P48298
GenBank Nucleotide #
NM_011330.3
NCBI Official Full Name
eotaxin
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
Ccl11
NCBI Official Synonym Symbols
Scya11; eotaxin
UniProt Protein Name
Eotaxin
UniProt Synonym Protein Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
UniProt Gene Name
Ccl11
UniProt Synonym Gene Names
Scya11
UniProt Entry Name
CCL11_MOUSE
NCBI Protein Information
eotaxin

UniProt Comments for Ccl11, Scya11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: chemokine activity; cytokine activity

Biological Process: regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; mast cell chemotaxis; eosinophil chemotaxis; actin filament organization; cytoskeleton organization and biogenesis; immune response; positive regulation of endothelial cell proliferation; inflammatory response; chemotaxis; positive regulation of cell migration
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Research Articles on Ccl11, Scya11

1. The chemokines monocyte chemotactic protein 1 (MCP1), MIP1alpha, MIP1beta, interferon gamma-induced protein 10 (IP-10), and eotaxin were induced in Saa1 TG mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ccl11, Scya11 active protein

 Reference Product  PubMed Publications
 Ccr3 active protein  >334 publications with Ccl11, Scya11 and Ccr3
 Ccl17 active protein  >85 publications with Ccl11, Scya11 and Ccl17
 Ccl22 active protein  >60 publications with Ccl11, Scya11 and Ccl22
 Ccr5 active protein  >60 publications with Ccl11, Scya11 and Ccr5
 Ccr2 active protein  >48 publications with Ccl11, Scya11 and Ccr2
 Ccr1 active protein  >47 publications with Ccl11, Scya11 and Ccr1
 Cxcr3 active protein  >25 publications with Ccl11, Scya11 and Cxcr3
 Cxcr4 active protein  >21 publications with Ccl11, Scya11 and Cxcr4
 Cxcr5 active protein  >1 publications with Ccl11, Scya11 and Cxcr5

Pathways associated with Ccl11, Scya11 active protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with Ccl11, Scya11 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >722 publications with Ccl11, Scya11 and Inflammation
 Respiratory Tract Diseases Antibodies  >583 publications with Ccl11, Scya11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >573 publications with Ccl11, Scya11 and Hypersensitivity
 Asthma Antibodies  >522 publications with Ccl11, Scya11 and Asthma
 Lung Diseases Antibodies  >479 publications with Ccl11, Scya11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >418 publications with Ccl11, Scya11 and Respiratory Hypersensitivity
 Necrosis Antibodies  >200 publications with Ccl11, Scya11 and Necrosis
 Bronchial Hyperreactivity Antibodies  >86 publications with Ccl11, Scya11 and Bronchial Hyperreactivity
 Drug Hypersensitivity Antibodies  >82 publications with Ccl11, Scya11 and Drug Hypersensitivity
 Dermatitis, Atopic Antibodies  >61 publications with Ccl11, Scya11 and Dermatitis, Atopic

Organs/Tissues associated with Ccl11, Scya11 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >496 publications with Ccl11, Scya11 and Lung
 Intestine Antibodies  >56 publications with Ccl11, Scya11 and Intestine
 Eye Antibodies  >52 publications with Ccl11, Scya11 and Eye
 Thymus Antibodies  >28 publications with Ccl11, Scya11 and Thymus
 Embryonic Tissue Antibodies  >12 publications with Ccl11, Scya11 and Embryonic Tissue
 Mixed Antibodies  >10 publications with Ccl11, Scya11 and Mixed
 Mammary Gland Antibodies  >3 publications with Ccl11, Scya11 and Mammary Gland
 Tongue Antibodies  >2 publications with Ccl11, Scya11 and Tongue
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