• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

BCA-1/BLC (CXCL13) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845098

Background: Human BCA-1 (B Cell-Attracting chemokine 1), also known as BLC or CXCL13, is a recently identified new CXC chemokines. Human BCA-1 is a highly effective attractant for human blood B lymphocytes, but was inactive on freshly isolated or IL-2… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
BCA-1/BLC (CXCL13) (CXCL13 ), Active Protein
Full Product Name
BCA-1 / BLC (CXCL13), human recombinant
Product Gene Name
CXCL13 active protein
Product Synonym Names
B cell Attracting Chemokine-1; CXCL13; BLC (mouse); BLR1 Ligand; Angie; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
Host
E Coli
Form/Format
Sterile filtered and lyophilized from 10 mM TFA
Appearance: Lyophilized protein
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
10.1 kDa
OMIM
605149
3D Structure
ModBase 3D Structure for O43927
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers or store at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10 ng/ml.
Results
1.0-10 ng/ml.
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for CXCL13 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CXCL13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL13 purchase

MBS845098 is an active protein targeting CXCL13 . Also known as BCA-1 / BLC (CXCL13), human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL13 . It may not necessarily be applicable to this product.

NCBI GI #
5453577
NCBI GeneID
10563
NCBI Accession #
NP_006410.1
UniProt Primary Accession #
O43927
UniProt Related Accession #
O43927
GenBank Nucleotide #
NM_006419.2
NCBI Official Full Name
C-X-C motif chemokine 13
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 13
NCBI Official Symbol
CXCL13
NCBI Official Synonym Symbols
BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
UniProt Protein Name
C-X-C motif chemokine 13
UniProt Synonym Protein Names
Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL13
UniProt Synonym Gene Names
BCA1; BLC; SCYB13; BCA-1
UniProt Entry Name
CXL13_HUMAN
NCBI Protein Information
C-X-C motif chemokine 13

NCBI Summary for CXCL13

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Show more

UniProt Comments for CXCL13

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CCR10 chemokine receptor binding; CXCR5 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; regulation of angiogenesis; positive regulation of integrin activation; positive regulation of cell-cell adhesion mediated by integrin; lymph node development; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response
Show more

Research Articles on CXCL13

1. After validation in larger patient groups, CXCR5 and CXCL13 may prove useful as biomarkers for nonsmall cell lung carcinoma Correspondingly, blockade of this axis could serve as an effective therapy for nonsmall cell lung carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL13 active protein

 Reference Product  PubMed Publications
 CXCR5 active protein  >199 publications with CXCL13 and CXCR5
 CXCL12 active protein  >136 publications with CXCL13 and CXCL12
 CCL21 active protein  >127 publications with CXCL13 and CCL21
 CCL19 active protein  >101 publications with CXCL13 and CCL19
 CCR7 active protein  >54 publications with CXCL13 and CCR7
 CXCL10 active protein  >52 publications with CXCL13 and CXCL10
 CXCL9 active protein  >32 publications with CXCL13 and CXCL9
 CXCR3 active protein  >28 publications with CXCL13 and CXCR3
 CCL25 active protein  >12 publications with CXCL13 and CCL25
 CCR10 active protein  >2 publications with CXCL13 and CCR10

Pathways associated with CXCL13 active protein

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with CXCL13 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >171 publications with CXCL13 and Inflammation
 Necrosis Antibodies  >64 publications with CXCL13 and Necrosis
 Disease Models, Animal Antibodies  >52 publications with CXCL13 and Disease Models, Animal
 Lung Diseases Antibodies  >34 publications with CXCL13 and Lung Diseases
 Carcinoma Antibodies  >32 publications with CXCL13 and Carcinoma
 Kidney Diseases Antibodies  >20 publications with CXCL13 and Kidney Diseases
 Hyperplasia Antibodies  >19 publications with CXCL13 and Hyperplasia
 Neoplasms, Experimental Antibodies  >18 publications with CXCL13 and Neoplasms, Experimental
 Liver Diseases Antibodies  >15 publications with CXCL13 and Liver Diseases
 Fibrosis Antibodies  >12 publications with CXCL13 and Fibrosis

Organs/Tissues associated with CXCL13 active protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >186 publications with CXCL13 and Lymph Node
 Spleen Antibodies  >83 publications with CXCL13 and Spleen
 Vascular Antibodies  >73 publications with CXCL13 and Vascular
 Bone Antibodies  >71 publications with CXCL13 and Bone
 Lung Antibodies  >45 publications with CXCL13 and Lung
 Kidney Antibodies  >24 publications with CXCL13 and Kidney
 Intestine Antibodies  >22 publications with CXCL13 and Intestine
 Muscle Antibodies  >21 publications with CXCL13 and Muscle
 Prostate Antibodies  >20 publications with CXCL13 and Prostate
 Pharynx Antibodies  >20 publications with CXCL13 and Pharynx
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000