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TGF-Beta3 (TGFB3) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845106

Background: Transforming growth factor beta3 (TGF-beta3) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Recombinant human TGF-beta3 is a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TGF-beta3 (TGFB3), Active Protein
Full Product Name
TGF-beta3, human recombinant
Product Gene Name
TGFB3 active protein
Product Synonym Names
Transforming Growth Factor-beta2; Human TGF-beta3; TGF-beta3,TGFbeta3; TGF beta3; h-TGF-beta3; rh-TGF-beta3; recombinant human TGF-beta3; recombinant TGF-beta; TGF
Host
E Coli
Form/Format
Protein solution (0.20mg/ml) containing 20% ethanol and 0.12 % acetic acid
Appearance: Liquid protein
Purity/Purification
>=98%
Preparation and Storage
4 degree C
Shelf Life: 12 months
Molecular Weight
25.5 kDa
OMIM
107970
3D Structure
ModBase 3D Structure for P10600
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
This protein solution should be stored at 4 degree C, stable for at least 3 months. For long term storage, it is recommended to add a carrier protein (0.1% HAS or BSA).
Endotoxin Level
<0.1 ng/mug
Biological Activity
MyBioSource's recombinant human TGF-beta3 is fully biologically active when compared to standard. The ED?? determined by cytotoxicity assay using the world health organization standard 98/608 as a direct comparison is <0.05 ng/ml, corresponding to a specific activity of >2 x 10? units/mg.
Results
<0.05 ng/ml
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for TGFB3 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of TGFB3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFB3 purchase

MBS845106 is an active protein targeting TGFB3. Also known as TGF-beta3, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFB3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
Protein Family
Transforming growth factor
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3

NCBI Summary for TGFB3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGFB3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Cell development/differentiation; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; SMAD protein nuclear translocation; female pregnancy; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; uterine wall breakdown; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; positive regulation of cell division; regulation of MAPKKK cascade; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGFB3

1. TGF-beta3 may contribute to the persistent intestinal dysfunction seen in gastroschisis-related intestinal dysfunction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFB3 active protein

 Reference Product  PubMed Publications
 TGFB2 active protein  >587 publications with TGFB3 and TGFB2
 SMAD2 active protein  >89 publications with TGFB3 and SMAD2
 SMAD3 active protein  >62 publications with TGFB3 and SMAD3
 SMAD4 active protein  >40 publications with TGFB3 and SMAD4
 TGFBR3 active protein  >28 publications with TGFB3 and TGFBR3
 TGFBR1 active protein  >12 publications with TGFB3 and TGFBR1
 TGFBR2 active protein  >12 publications with TGFB3 and TGFBR2
 SMAD6 active protein  >7 publications with TGFB3 and SMAD6
 FMOD active protein  >2 publications with TGFB3 and FMOD
 ACVRL1 active protein  >1 publications with TGFB3 and ACVRL1

Diseases associated with TGFB3 active protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >201 publications with TGFB3 and Fibrosis
 Disease Models, Animal Antibodies  >113 publications with TGFB3 and Disease Models, Animal
 Cleft Palate Antibodies  >113 publications with TGFB3 and Cleft Palate
 Cardiovascular Diseases Antibodies  >93 publications with TGFB3 and Cardiovascular Diseases
 Inflammation Antibodies  >83 publications with TGFB3 and Inflammation
 Necrosis Antibodies  >65 publications with TGFB3 and Necrosis
 Heart Diseases Antibodies  >56 publications with TGFB3 and Heart Diseases
 Lung Diseases Antibodies  >43 publications with TGFB3 and Lung Diseases
 Breast Neoplasms Antibodies  >41 publications with TGFB3 and Breast Neoplasms
 Hypertrophy Antibodies  >39 publications with TGFB3 and Hypertrophy

Organs/Tissues associated with TGFB3 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >381 publications with TGFB3 and Bone
 Connective Tissue Antibodies  >267 publications with TGFB3 and Connective Tissue
 Embryonic Tissue Antibodies  >152 publications with TGFB3 and Embryonic Tissue
 Bone Marrow Antibodies  >135 publications with TGFB3 and Bone Marrow
 Mouth Antibodies  >126 publications with TGFB3 and Mouth
 Heart Antibodies  >82 publications with TGFB3 and Heart
 Lung Antibodies  >81 publications with TGFB3 and Lung
 Eye Antibodies  >72 publications with TGFB3 and Eye
 Brain Antibodies  >71 publications with TGFB3 and Brain
 Liver Antibodies  >57 publications with TGFB3 and Liver
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