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UGDH Human Recombinant Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845136

Background: UGDH is part of the UDP-glucose/GDP-mannose dehydrogenase family and is a widely expressed enzyme localized in the liver. UGDH transfers UDP-glucose to UDP-glucuronate and thus takes part in the biosynthesis of glycosaminoglycans such as… More details

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Product Overview

Product Name
UGDH, Active Protein
Full Product Name
Human Recombinant UGDH
Product Gene Name
UGDH active protein
Product Synonym Names
UDP-glucose dehydrogenase; GDH; UDP-GlcDH; UDPGDH; UGD.; Human Recombinant UGDH
Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM FEIKKICCIG AGYVGGPTCS VIAHMCPEIR VTVVDVNESR INAWNSPTLP IYEPGLKEVV ESCRGKNLFF STNIDDAIKE ADLVFISVNT PTKTYGMGKG RAADLKYIEA CARRIVQNSN GYKIVTEKST VPVRAAESIR RIFDANTKPN LNLQVLSNPE FLAEGTAIKD LKNPDRVLIG GDETPEGQRA VQALCAVYEH WVPREKILTT NTWSSELSKL AANAFLAQRI SSINSISALC EATGADVEEV ATAIGMDQRI GNKFLKASVG FGGSCFQKDV LNLVYLCEAL NLPEVARYWQ QVIDMNDYQR RRFASRIIDS LFNTVTDKKI AILGFAFKKD TGDTRESSSI YISKYLMDEG AHLHIYDPKV PREQIVVDLS HPGVSEDDQV SRLVTISKDP YEACDGAHAV VICTEWDMFK ELDYERIHKK MLKPAFIFDG RRVLDGLHNE LQTIGFQIET IGKKVSSKRI PYAPSGEIPK FSLQDPPNKK PKV
Host
E Coli
Form/Format
0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1 mM DTT, 0.1 M NaCl, and 1 mM EDTA.
Appearance: Liquid
Purity/Purification
>=95%
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -80 degree C
Shelf Life: 12 months
Molecular Weight
59.5 kDa (533 aa, 1-494 aa + NT His-Tag)
OMIM
603370
3D Structure
ModBase 3D Structure for O60701
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Specific activity: >0.1 unit/ml.
Results
>0.1 unit/ml
Unit Definition
One unit will oxidize 1.0 umol of UDP-glucose to UDP-glucuronic acid per minute at pH 8.0 at 25 degree C.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for UGDH active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)
Applications Tested/Suitable for UGDH active protein
SDS-PAGE

Testing Data of UGDH active protein

Human Recombinant UGDH Active Protein – Cat# MBS845136

Other Notes

Small volumes of UGDH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UGDH purchase

MBS845136 is an active protein targeting UGDH. Also known as Human Recombinant UGDH. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for UGDH. It may not necessarily be applicable to this product.

NCBI GI #
296040443
NCBI GeneID
7358
NCBI Accession #
NP_001171629.1
UniProt Primary Accession #
O60701
UniProt Secondary Accession #
O60589; B3KUU2; B4DN25
UniProt Related Accession #
O60701
GenBank Nucleotide #
NM_001184700.1
NCBI Official Full Name
UDP-glucose 6-dehydrogenase isoform 2
NCBI Official Synonym Full Names
UDP-glucose 6-dehydrogenase
NCBI Official Symbol
UGDH
NCBI Official Synonym Symbols
GDH; UGD; UDPGDH; UDP-GlcDH
UniProt Protein Name
UDP-glucose 6-dehydrogenase
UniProt Gene Name
UGDH
UniProt Synonym Gene Names
UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH
UniProt Entry Name
UGDH_HUMAN
NCBI Protein Information
UDP-glucose 6-dehydrogenase

NCBI Summary for UGDH

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for UGDH

UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.22; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Oxidoreductase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Motility/polarity/chemotaxis; Carbohydrate Metabolism - ascorbate and aldarate

Chromosomal Location of Human Ortholog: 4p15.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity

Biological Process: glycosaminoglycan biosynthetic process; xenobiotic metabolic process; gastrulation with mouth forming second; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process
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Research Articles on UGDH

1. UGDH displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). We show that the structure of E* constrains UGDH in a conformation that favors feedback inhibition at physiological pH.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with UGDH active protein

 Reference Product  PubMed Publications
 UGT1A1 active protein  >1 publications with UGDH and UGT1A1
 UGP2 active protein  >1 publications with UGDH and UGP2

Pathways associated with UGDH active protein

 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Formation Of The Active Cofactor, UDP-glucuronate Pathway antibodies  Formation Of The Active Cofactor, UDP-glucuronate Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronidation Pathway antibodies  Glucuronidation Pathway Diagram
 Glucuronidation Pathway antibodies  Glucuronidation Pathway Diagram

Diseases associated with UGDH active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with UGDH and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with UGDH and Heart Diseases
 Congenital Abnormalities Antibodies  >3 publications with UGDH and Congenital Abnormalities
 Liver Diseases Antibodies  >2 publications with UGDH and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with UGDH and Nervous System Diseases
 Hyperglycemia Antibodies  >1 publications with UGDH and Hyperglycemia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with UGDH and Drug-Related Side Effects and Adverse Reactions
 Edema Antibodies  >1 publications with UGDH and Edema
 Poisoning Antibodies  >1 publications with UGDH and Poisoning
 Carcinoma, Hepatocellular Antibodies  >1 publications with UGDH and Carcinoma, Hepatocellular

Organs/Tissues associated with UGDH active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with UGDH and Liver
 Muscle Antibodies  >6 publications with UGDH and Muscle
 Prostate Antibodies  >3 publications with UGDH and Prostate
 Heart Antibodies  >3 publications with UGDH and Heart
 Bone Antibodies  >3 publications with UGDH and Bone
 Lung Antibodies  >2 publications with UGDH and Lung
 Embryonic Tissue Antibodies  >2 publications with UGDH and Embryonic Tissue
 Kidney Antibodies  >2 publications with UGDH and Kidney
 Eye Antibodies  >2 publications with UGDH and Eye
 Brain Antibodies  >2 publications with UGDH and Brain
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