GDF9 (GDF-9) Active Protein

Name: GDF-9 Active Protein; GDF9; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845137
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845137

Background: GDF-9 is a member of the TGF-beta superfamily of growth and differentiation factors, and is highly homologous to GDF-3. Unlike most TGF-family members, GDF-9 and GDF-3 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GDF9 (GDF-9), Active Protein

Full Product Name

GDF9, human recombinant

Product Gene Name

GDF-9 active protein

Product Synonym Names

Growth/differentiation factor 9

Host

E Coli

Form/Format

Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

31.2 kDa

OMIM

601918

3D Structure

ModBase 3D Structure for O60383

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Endotoxin Level

<0.1 ng/mug

Biological Activity

Test in process

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for GDF-9 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of GDF-9 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF-9 purchase

MBS845137 is an active protein targeting GDF-9. Also known as GDF9, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF-9. It may not necessarily be applicable to this product.

NCBI GI #

572152931

NCBI GeneID

2661

NCBI Accession #

NP_001275753.1

UniProt Primary Accession #

O60383

UniProt Secondary Accession #

Q4VAW5

UniProt Related Accession #

O60383

GenBank Nucleotide #

NM_001288824.2

NCBI Official Full Name

growth/differentiation factor 9 isoform 2

NCBI Official Synonym Full Names

growth differentiation factor 9

NCBI Official Symbol

GDF9

UniProt Protein Name

Growth/differentiation factor 9

UniProt Gene Name

GDF9

UniProt Synonym Gene Names

GDF-9

UniProt Entry Name

GDF9_HUMAN

NCBI Protein Information

growth/differentiation factor 9

NCBI Summary for GDF-9

This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

UniProt Comments for GDF-9

GDF9: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; oocyte growth; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; positive regulation of cell proliferation; female gamete generation; negative regulation of cell growth; cell development

Research Articles on GDF-9

1. Eleven unique copy number changes are identified in a total of 11 patients, including a tandem duplication of 475 bp, containing part of the GDF9 gene promoter region.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF-9 active protein

Reference Product	PubMed Publications
KITLG active protein	>38 publications with GDF-9 and KITLG
BMPR2 active protein	>34 publications with GDF-9 and BMPR2
SMAD2 active protein	>23 publications with GDF-9 and SMAD2
BMPR1B active protein	>22 publications with GDF-9 and BMPR1B
HAS2 active protein	>18 publications with GDF-9 and HAS2
CYP19A1 active protein	>15 publications with GDF-9 and CYP19A1
FSHR active protein	>12 publications with GDF-9 and FSHR
LHCGR active protein	>10 publications with GDF-9 and LHCGR
TGFBR1 active protein	>8 publications with GDF-9 and TGFBR1
CYP17A1 active protein	>6 publications with GDF-9 and CYP17A1

Pathways associated with GDF-9 active protein

Products by Pathway	Pathway Diagram
Ovarian Infertility Genes Pathway antibodies	Ovarian Infertility Genes Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram

Diseases associated with GDF-9 active protein

Disease Name	Pubmed Publications
Infertility, Female Antibodies	>63 publications with GDF-9 and Infertility, Female
Ovarian Diseases Antibodies	>62 publications with GDF-9 and Ovarian Diseases
Polycystic Ovary Syndrome Antibodies	>16 publications with GDF-9 and Polycystic Ovary Syndrome
Infertility, Male Antibodies	>7 publications with GDF-9 and Infertility, Male
Necrosis Antibodies	>5 publications with GDF-9 and Necrosis
Kidney Diseases Antibodies	>4 publications with GDF-9 and Kidney Diseases
Disorders of Sex Development Antibodies	>4 publications with GDF-9 and Disorders of Sex Development
Cardiovascular Diseases Antibodies	>3 publications with GDF-9 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>3 publications with GDF-9 and Adenocarcinoma
Prenatal Injuries Antibodies	>2 publications with GDF-9 and Prenatal Injuries

Organs/Tissues associated with GDF-9 active protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>17 publications with GDF-9 and Testis
Kidney Antibodies	>10 publications with GDF-9 and Kidney
Brain Antibodies	>10 publications with GDF-9 and Brain
Liver Antibodies	>5 publications with GDF-9 and Liver
Adrenal Gland Antibodies	>2 publications with GDF-9 and Adrenal Gland
Mammary Gland Antibodies	>1 publications with GDF-9 and Mammary Gland