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CNTF Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845139

Background: CNTF (Ciliary Neurotrophic Factor) is a potent neural factor that was originally characterized as a survivability factor for chick ciliary neurons in vitro. CNTF has also been shown to promote survivability and differentiation of other neuronal… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CNTF, Active Protein
Full Product Name
CNTF, human recombinant
Product Gene Name
CNTF active protein
Product Synonym Names
HCNTF; CNTF; Ciliary Neurotrophic Factor.
Host
E Coli
Form/Format
Sterile filtered and lyophilized without additives
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
22.9 kDa
OMIM
118945
3D Structure
ModBase 3D Structure for P26441
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in 5 mM Sodium Phosphate, pH 7.5 to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use
Endotoxin Level
<0.1 ng/mug
Biological Activity
The ED?? as determined by the dose-dependent proliferation of human TF-1 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 10? units/mg.
Results
< 2 ng/ml
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for CNTF active protein
SDS-PAGE; HPLC

Testing Data of CNTF active protein

CNTF Active Protein – Cat# MBS845139

Other Notes

Small volumes of CNTF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNTF purchase

MBS845139 is an active protein targeting CNTF. Also known as CNTF, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CNTF. It may not necessarily be applicable to this product.

NCBI GI #
4758020
NCBI GeneID
1270
NCBI Accession #
NP_000605.1
UniProt Primary Accession #
P26441
UniProt Secondary Accession #
B2RAB2
UniProt Related Accession #
P26441
GenBank Nucleotide #
NM_000614.3
NCBI Official Full Name
ciliary neurotrophic factor
NCBI Official Synonym Full Names
ciliary neurotrophic factor
NCBI Official Symbol
CNTF
NCBI Official Synonym Symbols
HCNTF
UniProt Protein Name
Ciliary neurotrophic factor
Protein Family
Ciliary neurotrophic factor
UniProt Gene Name
CNTF
UniProt Synonym Gene Names
CNTF
UniProt Entry Name
CNTF_HUMAN
NCBI Protein Information
ciliary neurotrophic factor

NCBI Summary for CNTF

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
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UniProt Comments for CNTF

CNTF: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. Belongs to the CNTF family.

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: interleukin-6 receptor binding; growth factor activity; ciliary neurotrophic factor receptor binding

Biological Process: negative regulation of photoreceptor cell differentiation; positive regulation of cell proliferation; regulation of retinal cell programmed cell death; neuron development; negative regulation of neuron apoptosis; signal transduction; muscle morphogenesis; growth; positive regulation of tyrosine phosphorylation of Stat3 protein
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Research Articles on CNTF

1. the biological effects of CNTF on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells and the underlying molecular mechanism of this effect were investigated for the first time

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CNTF active protein

 Reference Product  PubMed Publications
 STAT3 active protein  >214 publications with CNTF and STAT3
 OSM active protein  >185 publications with CNTF and OSM
 LIFR active protein  >129 publications with CNTF and LIFR
 CNTFR active protein  >115 publications with CNTF and CNTFR
 IL6ST active protein  >112 publications with CNTF and IL6ST
 IL11 active protein  >72 publications with CNTF and IL11
 IL6 active protein  >16 publications with CNTF and IL6
 APOE active protein  >4 publications with CNTF and APOE
 IL6R active protein  >1 publications with CNTF and IL6R

Pathways associated with CNTF active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with CNTF active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >618 publications with CNTF and Nervous System Diseases
 Death Antibodies  >389 publications with CNTF and Death
 Brain Diseases Antibodies  >309 publications with CNTF and Brain Diseases
 Disease Models, Animal Antibodies  >255 publications with CNTF and Disease Models, Animal
 Nerve Degeneration Antibodies  >198 publications with CNTF and Nerve Degeneration
 Inflammation Antibodies  >115 publications with CNTF and Inflammation
 Necrosis Antibodies  >92 publications with CNTF and Necrosis
 Weight Loss Antibodies  >76 publications with CNTF and Weight Loss
 Atrophy Antibodies  >70 publications with CNTF and Atrophy
 Movement Disorders Antibodies  >59 publications with CNTF and Movement Disorders

Organs/Tissues associated with CNTF active protein

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1843 publications with CNTF and Nerve
 Brain Antibodies  >1315 publications with CNTF and Brain
 Eye Antibodies  >403 publications with CNTF and Eye
 Muscle Antibodies  >336 publications with CNTF and Muscle
 Embryonic Tissue Antibodies  >335 publications with CNTF and Embryonic Tissue
 Ganglia Antibodies  >330 publications with CNTF and Ganglia
 Spinal Cord Antibodies  >285 publications with CNTF and Spinal Cord
 Blood Antibodies  >211 publications with CNTF and Blood
 Bone Antibodies  >114 publications with CNTF and Bone
 Vascular Antibodies  >81 publications with CNTF and Vascular
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