Procathepsin E/Cathepsin E (CTSE) Active Protein

Name: CTSE Active Protein; Procathepsin E/Cathepsin E; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845148
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845148

Background: Cathepsin E (EC: 3.4.23.34) (CTSE) is an intracellular gastric aspartyl protease. It was originally identified as a cathepsin D-like acid protease. It is active in acidic conditions in a pH range from 2.5 to 5.5. In vitro experiments have… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Procathepsin E/Cathepsin E (CTSE), Active Protein

Full Product Name

Procathepsin E / Cathepsin E, human recombinant

Product Gene Name

CTSE active protein

Product Synonym Names

CTSE; Cathepsin E; Procathepsin E

Host

E Coli

Form/Format

Lyophilized from 5 mg/ml solution in a proprietary buffer
Appearance: Lyophilized

Purity/Purification

>=90%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

43.6 kDa (20-401 aa + N-terminal polyhistidine tag)

OMIM

116890

3D Structure

ModBase 3D Structure for P14091

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute with water to 0.5-1 mg/ml. Aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

Activity (Specifications/test method)

MyBioSource's Procathepsin E/ Cathepsin E has a specific activity of >500 mU/mg. The Procathepsin E is auto activated to form Cathepsin E after reconstitution. MyBioSource's Procathepsin E/ Cathepsin E protein is more stable than a mixture of these proteins made from a non-E.Coli source.

Biological Activity

Results

>500 mU/mg

Unit Definition

1 U = 1 nmole/min digestion of Cathepsin E fluorogenic substrate Mca-GKPILFFRLK(Dnp)-R-NH2 substrate in 50 mM sodium acetate, 0.5 M NaCl, pH 3.0 buffer.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for CTSE active protein

Applications Tested/Suitable for CTSE active protein

SDS-PAGE

Other Notes

Small volumes of CTSE active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSE purchase

MBS845148 is an active protein targeting CTSE. Also known as Procathepsin E / Cathepsin E, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSE. It may not necessarily be applicable to this product.

NCBI GI #

4503145

NCBI GeneID

1510

NCBI Accession #

NP_001901.1

UniProt Primary Accession #

P14091

UniProt Secondary Accession #

Q5TZ01; Q5TZ02; Q9NY58; Q9UCE3; Q9UCE4

UniProt Related Accession #

P14091

GenBank Nucleotide #

NM_001910.3

NCBI Official Full Name

cathepsin E isoform a preproprotein

NCBI Official Synonym Full Names

cathepsin E

NCBI Official Symbol

CTSE

NCBI Official Synonym Symbols

CATE

UniProt Protein Name

Cathepsin E

Protein Family

Cathepsin

UniProt Gene Name

CTSE

UniProt Entry Name

CATE_HUMAN

NCBI Protein Information

cathepsin E

NCBI Summary for CTSE

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CTSE

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.34; Protease

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: endosome

Molecular Function: protein homodimerization activity; aspartic-type endopeptidase activity

Biological Process: protein autoprocessing; digestion; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Research Articles on CTSE

1. Decreased activity of cathepsin E produced by decidual macrophages might be responsible for the induction of miscarriages in some recurrent miscarriage patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSE active protein

Reference Product	PubMed Publications
PCSK1 active protein	>1 publications with CTSE and PCSK1

Pathways associated with CTSE active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
MHC Class II Antigen Presentation Pathway antibodies	MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with CTSE active protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>3 publications with CTSE and Liver Diseases
Inflammation Antibodies	>3 publications with CTSE and Inflammation
Urinary Bladder Neoplasms Antibodies	>2 publications with CTSE and Urinary Bladder Neoplasms
Hypertrophy Antibodies	>2 publications with CTSE and Hypertrophy
Fibrosis Antibodies	>2 publications with CTSE and Fibrosis
Neoplasms, Experimental Antibodies	>2 publications with CTSE and Neoplasms, Experimental
Breast Neoplasms Antibodies	>2 publications with CTSE and Breast Neoplasms
Hyperplasia Antibodies	>2 publications with CTSE and Hyperplasia
Necrosis Antibodies	>2 publications with CTSE and Necrosis
Hepatomegaly Antibodies	>1 publications with CTSE and Hepatomegaly

Organs/Tissues associated with CTSE active protein

Organ/Tissue Name	Pubmed Publications
Stomach Antibodies	>8 publications with CTSE and Stomach
Liver Antibodies	>3 publications with CTSE and Liver
Lung Antibodies	>3 publications with CTSE and Lung
Pancreas Antibodies	>3 publications with CTSE and Pancreas
Bone Marrow Antibodies	>2 publications with CTSE and Bone Marrow
Bladder Antibodies	>2 publications with CTSE and Bladder
Muscle Antibodies	>1 publications with CTSE and Muscle
Brain Antibodies	>1 publications with CTSE and Brain
Intestine Antibodies	>1 publications with CTSE and Intestine