TDGF1 Active Protein

Name: TDGF1 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845152
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845152

Background: Teratocarcinoma-derived growth factor 1, also known as epidermal growth factor-like cripto protein CR1, CRGF, and TDGF1, is a cell membrane which contains one EGF-like domain. In humans, TDGF1 is highly expressed in germ cell tumors and in colon… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TDGF1, Active Protein

Full Product Name

TDGF1, human recombinant

Product Gene Name

TDGF1 active protein

Product Synonym Names

CRIPTO1; CRIPTO-1; CRGF; Teratocarcinoma-Derived Growth Factor 1; TDGF1; CR1.

Sequence

A DNA sequence encoding the human TDGF1 (AAH22393. 1) (Met 1 - Thr 172) with a C-terminal polyhistid ine tag was expressed.

Host

Human cells

Form/Format

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Appearance: Lyophilized protein

Purity/Purification

>=95%

Preparation and Storage

At -70 degree C
Shelf Life: 12 months

Molecular Weight

17.4 kDa

OMIM

187395

3D Structure

ModBase 3D Structure for P13385

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in sterile PBS

Biological Activity

Measured by its binding ability in a functional ELISA Immobilized human TDGF1 at 2 mug/ml (100 mul/well) can bind human ALK4 with a linear range of 0.0068 - 0.16 mug/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TDGF1 active protein

Cytokines; Growth Factors & Hormones; Cytokines; Growth Factors & Hormone (A-Z) Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Cytok

Applications Tested/Suitable for TDGF1 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of TDGF1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TDGF1 purchase

MBS845152 is an active protein targeting TDGF1. Also known as TDGF1, human recombinant. Host: Human cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TDGF1. It may not necessarily be applicable to this product.

NCBI GI #

292494883

NCBI GeneID

6997

NCBI Accession #

NP_001167607.1

UniProt Primary Accession #

P13385

UniProt Secondary Accession #

Q8TCC1

UniProt Related Accession #

P13385

GenBank Nucleotide #

NM_001174136.1

NCBI Official Full Name

teratocarcinoma-derived growth factor 1 isoform 2

NCBI Official Synonym Full Names

teratocarcinoma-derived growth factor 1

NCBI Official Symbol

TDGF1

NCBI Official Synonym Symbols

CR; CRGF; CRIPTO

UniProt Protein Name

Teratocarcinoma-derived growth factor 1

UniProt Synonym Protein Names

Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1

Protein Family

Teratocarcinoma-derived growth factor

UniProt Gene Name

TDGF1

UniProt Synonym Gene Names

CRIPTO; CRGF

UniProt Entry Name

TDGF1_HUMAN

NCBI Protein Information

teratocarcinoma-derived growth factor 1

NCBI Summary for TDGF1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

UniProt Comments for TDGF1

TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Membrane protein, GPI anchor; Cell adhesion; Cell cycle regulation; Motility/polarity/chemotaxis; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft

Molecular Function: protein binding; growth factor activity; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; in utero embryonic development; activation of MAPK activity; somatic stem cell maintenance; heart development; regulation of signal transduction; gastrulation; morphogenesis of a branching structure; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of fibroblast proliferation; cell migration during sprouting angiogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cell migration; negative regulation of apoptosis

Research Articles on TDGF1

1. Snail represses Cripto-1 gene by direct transcriptional interaction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TDGF1 active protein

Reference Product	PubMed Publications
NODAL active protein	>88 publications with TDGF1 and NODAL
NANOG active protein	>30 publications with TDGF1 and NANOG
SMAD2 active protein	>27 publications with TDGF1 and SMAD2
ACVR1B active protein	>20 publications with TDGF1 and ACVR1B
GDF3 active protein	>11 publications with TDGF1 and GDF3
SOX2 active protein	>11 publications with TDGF1 and SOX2
ACVR1C active protein	>4 publications with TDGF1 and ACVR1C
ACVR2A active protein	>3 publications with TDGF1 and ACVR2A
ACVR2B active protein	>1 publications with TDGF1 and ACVR2B

Diseases associated with TDGF1 active protein

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>31 publications with TDGF1 and Skin Diseases
Neoplasm Metastasis Antibodies	>22 publications with TDGF1 and Neoplasm Metastasis
Adenocarcinoma Antibodies	>20 publications with TDGF1 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>13 publications with TDGF1 and Neoplasms, Experimental
Genital Diseases, Female Antibodies	>12 publications with TDGF1 and Genital Diseases, Female
Liver Neoplasms Antibodies	>12 publications with TDGF1 and Liver Neoplasms
Nervous System Diseases Antibodies	>12 publications with TDGF1 and Nervous System Diseases
Liver Diseases Antibodies	>9 publications with TDGF1 and Liver Diseases
Holoprosencephaly Antibodies	>9 publications with TDGF1 and Holoprosencephaly
Disease Models, Animal Antibodies	>8 publications with TDGF1 and Disease Models, Animal

Organs/Tissues associated with TDGF1 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>64 publications with TDGF1 and Embryonic Tissue
Muscle Antibodies	>24 publications with TDGF1 and Muscle
Brain Antibodies	>13 publications with TDGF1 and Brain
Liver Antibodies	>12 publications with TDGF1 and Liver
Testis Antibodies	>7 publications with TDGF1 and Testis
Uterus Antibodies	>6 publications with TDGF1 and Uterus
Kidney Antibodies	>4 publications with TDGF1 and Kidney
Prostate Antibodies	>4 publications with TDGF1 and Prostate
Intestine Antibodies	>4 publications with TDGF1 and Intestine
Spleen Antibodies	>3 publications with TDGF1 and Spleen