Human Recombinant TXN2 Active Protein – Cat# MBS845162

Thioredoxin 2 (TXN2) Human Recombinant Active Protein

Name: TXN2 Active Protein; Thioredoxin 2; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS845162
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845162

Background: Thioredoxin 2 also known as mitochondrial Thioredoxin in humans is encoded by the TXN2 gene. This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Thioredoxin 2 (TXN2), Active Protein

Full Product Name

Human Recombinant Thioredoxin 2

Product Gene Name

TXN2 active protein

Product Synonym Names

MTRX; TRX2; MT-TRX; Human Recombinant Thioredoxin 2

Sequence

MTTFNIQDGP DFQDRVVNSE TPVVVDFHAQ WCGPCKILGP RLEKMVAKQH GKVVMAKVDI DDHTDLAIEY EVSAVPTVLA MKNGDVVDKF VGIKDEDQLE AFLKKLIG

Host

E Coli

Form/Format

1 mg/ml solution in PBS (pH 7.4).
Appearance: Liquid

Purity/Purification

>=95%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

11 kDa

OMIM

609063

3D Structure

ModBase 3D Structure for Q99757

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is 3-4 A650/min/mg.

Unit Definition

Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25 degree C for 1 minute.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for TXN2 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for TXN2 active protein

SDS-PAGE

Other Notes

Small volumes of TXN2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXN2 purchase

MBS845162 is an active protein targeting TXN2. Also known as Human Recombinant Thioredoxin 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TXN2. It may not necessarily be applicable to this product.

NCBI GI #

21361403

NCBI GeneID

25828

NCBI Accession #

NP_036605.2

UniProt Primary Accession #

Q99757

UniProt Secondary Accession #

Q5JZA0; Q6FH60; Q9UH29

UniProt Related Accession #

Q99757

GenBank Nucleotide #

NM_012473.3

NCBI Official Full Name

thioredoxin, mitochondrial

NCBI Official Synonym Full Names

thioredoxin 2

NCBI Official Symbol

TXN2

NCBI Official Synonym Symbols

MTRX; TRX2; MT-TRX

UniProt Protein Name

Thioredoxin, mitochondrial

UniProt Synonym Protein Names

Thioredoxin-2

Protein Family

Thioredoxin-like protein

UniProt Gene Name

TXN2

UniProt Synonym Gene Names

TRX2; MTRX; Mt-Trx

UniProt Entry Name

THIOM_HUMAN

NCBI Protein Information

thioredoxin, mitochondrial

NCBI Summary for TXN2

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

UniProt Comments for TXN2

TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus

Molecular Function: peptide-methionine-(S)-S-oxide reductase activity; protein disulfide oxidoreductase activity; protein complex binding; peptide-methionine (R)-S-oxide reductase activity

Biological Process: response to drug; cellular response to nutrient levels; response to reactive oxygen species; cell redox homeostasis; response to glucose stimulus; response to hypoxia; response to hormone stimulus; response to axon injury; response to organic cyclic substance; response to nutrient; glycerol ether metabolic process

Research Articles on TXN2

1. The Grx2 system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TXN2 active protein

Reference Product	PubMed Publications
PRDX3 active protein	>10 publications with TXN2 and PRDX3
TXNRD2 active protein	>10 publications with TXN2 and TXNRD2
SOD2 active protein	>9 publications with TXN2 and SOD2
MAP3K5 active protein	>7 publications with TXN2 and MAP3K5
PRDX1 active protein	>2 publications with TXN2 and PRDX1
TFAM active protein	>2 publications with TXN2 and TFAM
EIF4E active protein	>1 publications with TXN2 and EIF4E

Pathways associated with TXN2 active protein

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Oxidative Stress Pathway antibodies	Oxidative Stress Pathway Diagram

Diseases associated with TXN2 active protein

Disease Name	Pubmed Publications
Death Antibodies	>21 publications with TXN2 and Death
Nervous System Diseases Antibodies	>10 publications with TXN2 and Nervous System Diseases
Brain Diseases Antibodies	>6 publications with TXN2 and Brain Diseases
Heart Diseases Antibodies	>5 publications with TXN2 and Heart Diseases
Necrosis Antibodies	>5 publications with TXN2 and Necrosis
Liver Diseases Antibodies	>4 publications with TXN2 and Liver Diseases
Inflammation Antibodies	>4 publications with TXN2 and Inflammation
Lung Neoplasms Antibodies	>3 publications with TXN2 and Lung Neoplasms
Fibrosis Antibodies	>3 publications with TXN2 and Fibrosis
Fatty Liver Antibodies	>2 publications with TXN2 and Fatty Liver

Organs/Tissues associated with TXN2 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>12 publications with TXN2 and Liver
Vascular Antibodies	>10 publications with TXN2 and Vascular
Brain Antibodies	>10 publications with TXN2 and Brain
Heart Antibodies	>9 publications with TXN2 and Heart
Muscle Antibodies	>7 publications with TXN2 and Muscle
Blood Antibodies	>6 publications with TXN2 and Blood
Lung Antibodies	>5 publications with TXN2 and Lung
Eye Antibodies	>5 publications with TXN2 and Eye
Nerve Antibodies	>4 publications with TXN2 and Nerve
Kidney Antibodies	>3 publications with TXN2 and Kidney