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IL20RB/Il-20r2 (IL20RB) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845182

Background: Interleukin-20 receptor subunit beta (IL20RB) is also known as IL-20R2, DIRS1, which belongs to the type II cytokine receptor family. IL20RB / IL-20R2 contains two fibronectin type-III domains. IL20RB / IL-20R2 is widely expressed with highest… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL20RB/IL-20R2, Active Protein
Full Product Name
Human CellExp IL20RB / IL-20R2, human recombinant
Product Gene Name
IL20RB active protein
Product Synonym Names
IL20RB; IL-20R2; IL-20R-beta; DIRS1; FNDC6
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 mum filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized
Purity/Purification
>=90%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
This protein fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 49.1 kDa. The predicted N-terminus is Asp 30. As a result of glycosylation, DTT-reduced Protein migrates as 50 kDa and non-reduced protein migrates as 100 kDa.
OMIM
605621
3D Structure
ModBase 3D Structure for Q6UXL0
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
Endotoxin Level
<1 EU/mug by LAL method
Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human IL?19 protein is present at 0.2 ug/mL, the concentration of rhIL20RB Fc Chimera that produces 50% of the optimal binding response is approximately 5?50 ng/ml.
Results
Measured by its binding ability in a functional ELISA. When Recombinant Human IL?19 protein is present at 0.2 ug/mL, the concentration of rhIL20RB Fc Chimera that produces 50% of the optimal binding response is approximately 5?50 ng/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for IL20RB active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth
Applications Tested/Suitable for IL20RB active protein
SDS-PAGE

Testing Data of IL20RB active protein

IL20RB Active Protein – Cat# MBS845182

Other Notes

Small volumes of IL20RB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL20RB purchase

MBS845182 is an active protein targeting IL20RB. Also known as Human CellExp IL20RB / IL-20R2, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL20RB. It may not necessarily be applicable to this product.

NCBI GI #
40255073
NCBI GeneID
53833
NCBI Accession #
NP_653318.2
UniProt Primary Accession #
Q6UXL0
UniProt Secondary Accession #
Q6P438; Q8IYY5; Q8TAJ7; B4DL40
UniProt Related Accession #
Q6UXL0
GenBank Nucleotide #
NM_144717.3
NCBI Official Full Name
interleukin-20 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 20 receptor beta
NCBI Official Symbol
IL20RB
NCBI Official Synonym Symbols
DIRS1; FNDC6; IL-20R2
UniProt Protein Name
Interleukin-20 receptor subunit beta
UniProt Synonym Protein Names
Fibronectin type III domain containing 6; FNDC6; IL-20R2
Protein Family
Interleukin-20 receptor
UniProt Gene Name
IL20RB
UniProt Synonym Gene Names
DIRS1; IL-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6
UniProt Entry Name
I20RB_HUMAN
NCBI Protein Information
interleukin-20 receptor subunit beta

NCBI Summary for IL20RB

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

UniProt Comments for IL20RB

IL20RB: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-20 binding

Biological Process: positive regulation of interleukin-4 production; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; immune response-inhibiting signal transduction; homeostasis of number of cells within a tissue; negative regulation of interferon-gamma production; cytokine and chemokine mediated signaling pathway; negative regulation of type IV hypersensitivity; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production
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Research Articles on IL20RB

1. Trabecular meshwork cells express IL-20 receptors; Mutation of the T104 residue in IL-20R2 leads to a reduction in STAT3 phosphorylation as well as decreased matrix metalloproteinase activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL20RB active protein

 Reference Product  PubMed Publications
 IL19 active protein  >3 publications with IL20RB and IL19
 IL20 active protein  >3 publications with IL20RB and IL20
 IL29 active protein  >2 publications with IL20RB and IL29
 IL26 active protein  >2 publications with IL20RB and IL26
 IL20RA active protein  >2 publications with IL20RB and IL20RA
 IL10 active protein  >1 publications with IL20RB and IL10
 IL22 active protein  >1 publications with IL20RB and IL22
 IL24 active protein  >1 publications with IL20RB and IL24

Pathways associated with IL20RB active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with IL20RB active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with IL20RB and Inflammation

Organs/Tissues associated with IL20RB active protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with IL20RB and Skin
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