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MIP-1alpha (CCL3) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845183

Background: Rat macrophage inflammatory protein-1alpha (MIP-1alpha) is an 8.0 kDa protein containing 69 amino acid residues. It plays an important role in the inflammatory response of blood monocytes and tissue microphages. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MIP-1alpha (CCL3), Active Protein
Full Product Name
MIP-1alpha, rat recombinant
Product Gene Name
CCL3 active protein
Product Synonym Names
Small inducible cytokine A3; CCL3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; SIS-beta; PAT 464,1; chemokine (C-C motif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78alpha; TY-5; SIS-alpha; Heparin-binding chemotaxis protein; L2G25B;
Host
E Coli
Form/Format
Sterile filtered and lyophilized with no additives
Appearance: Lyophilized protein
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
7.8 kDa
3D Structure
ModBase 3D Structure for P50229
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract rat peripheral macrophages using a concentration range of 50-100 ng/ml.
Results
50-100 ng/ml
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CCL3 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for CCL3 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CCL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL3 purchase

MBS845183 is an active protein targeting CCL3. Also known as MIP-1alpha, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL3. It may not necessarily be applicable to this product.

NCBI GI #
40254794
NCBI GeneID
25542
NCBI Accession #
NP_037157.2
UniProt Primary Accession #
P50229
UniProt Secondary Accession #
A1EC87
UniProt Related Accession #
P50229
GenBank Nucleotide #
NM_013025.2
NCBI Official Full Name
C-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 3
NCBI Official Symbol
Ccl3
NCBI Official Synonym Symbols
Scya3; MIP-1a
UniProt Protein Name
C-C motif chemokine 3
UniProt Synonym Protein Names
Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3
Protein Family
C-C motif chemokine
UniProt Gene Name
Ccl3
UniProt Synonym Gene Names
Mip1a; Scya3; MIP-1-alpha
UniProt Entry Name
CCL3_RAT
NCBI Protein Information
C-C motif chemokine 3

NCBI Summary for CCL3

mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]

UniProt Comments for CCL3

Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
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Research Articles on CCL3

1. The results of this study suggest a contribution of CCL3 in the spinal dorsal horn to paclitaxel-induced allodynia and may provide new therapeutic targets for paclitaxel-induced painful neuropathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL3 active protein

 Reference Product  PubMed Publications
 Ccl4 active protein  >1647 publications with CCL3 and Ccl4
 Ccl2 active protein  >936 publications with CCL3 and Ccl2
 Ccl5 active protein  >933 publications with CCL3 and Ccl5
 Ccr5 active protein  >518 publications with CCL3 and Ccr5
 Ccr1 active protein  >286 publications with CCL3 and Ccr1
 Ccl11 active protein  >121 publications with CCL3 and Ccl11
 Ccl7 active protein  >77 publications with CCL3 and Ccl7
 Ccr3 active protein  >70 publications with CCL3 and Ccr3
 Ccl17 active protein  >55 publications with CCL3 and Ccl17
 Ccbp2 active protein  >4 publications with CCL3 and Ccbp2

Pathways associated with CCL3 active protein

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with CCL3 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >929 publications with CCL3 and Inflammation
 Necrosis Antibodies  >524 publications with CCL3 and Necrosis
 Disease Models, Animal Antibodies  >323 publications with CCL3 and Disease Models, Animal
 Lung Diseases Antibodies  >248 publications with CCL3 and Lung Diseases
 HIV Infections Antibodies  >189 publications with CCL3 and HIV Infections
 Cardiovascular Diseases Antibodies  >178 publications with CCL3 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >108 publications with CCL3 and Hypersensitivity
 Liver Diseases Antibodies  >99 publications with CCL3 and Liver Diseases
 Fibrosis Antibodies  >83 publications with CCL3 and Fibrosis
 Pneumonia Antibodies  >74 publications with CCL3 and Pneumonia

Organs/Tissues associated with CCL3 active protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >43 publications with CCL3 and Connective Tissue
 Adipose Tissue Antibodies  >24 publications with CCL3 and Adipose Tissue
 Inner Ear Antibodies  >1 publications with CCL3 and Inner Ear
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