Human Recombinant GSR Active Protein – Cat# MBS845193

GSR Human Recombinant Active Protein

Name: GSR Active Protein; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS845193
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845193

Background: Glutathione reductase, also known as GSR or GR, is an enzyme that reduces glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. In most eukaryotic cells, GSR maintains the ratio of GSH / GSSG, and… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GSR, Active Protein

Full Product Name

Human Recombinant GSR

Product Gene Name

GSR active protein

Product Synonym Names

Glutathione reductase; GLUR; GRD1.; Human Recombinant GSR

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAMACRQ EPQPQGPPPA AGAVASYDYL VIGGGSGGLA SARRAAELGA RAAVVESHKL GGTCVNVGCV PKKVMWNTAV HSEFMHDHAD YGFPSCEGKF NWRVIKEKRD AYVSRLNAIY QNNLTKSHIE IIRGHAAFTS DPKPTIEVSG KKYTAPHILI ATGGMPSTPH ESQIPGASLG ITSDGFFQLE ELPGRSVIVG AGYIAVEMAG ILSALGSKTS LMIRHDKVLR SFDSMISTNC TEELENAGVE VLKFSQVKEV KKTLSGLEVS MVTAVPGRLP VMTMIPDVDC LLWAIGRVPN TKDLSLNKLG IQTDDKGHII VDEFQNTNVK GIYAVGDVCG KALLTPVAIA AGRKLAHRLF EYKEDSKLDY NNIPTVVFSH PPIGTVGLTE DEAIHKYGIE NVKTYSTSFT PMYHAVTKRK TKCVMKMVCA NKEEKVVGIH MQGLGCDEML QGFAVAVKMG ATKADFDNTV AIHPTSSEEL VTLR

Host

E Coli

Form/Format

1 mg/ml solution in 20 mM Tris-HCl (pH 8.0) containing 1 mM DTT, 0.1 M NaCl and 10% glycerol.
Appearance: Liquid

Purity/Purification

>=95%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

54.3 kDa

OMIM

138300

3D Structure

ModBase 3D Structure for P00390

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity: > 29 units/ml.

Unit Definition

One unit will reduce 1.0 umol of oxidized glutathione per minute at pH 7.5 at 25 degree C

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for GSR active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for GSR active protein

SDS-PAGE

Other Notes

Small volumes of GSR active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSR purchase

MBS845193 is an active protein targeting GSR. Also known as Human Recombinant GSR. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GSR. It may not necessarily be applicable to this product.

NCBI GI #

50301238

NCBI GeneID

2936

NCBI Accession #

NP_000628.2

UniProt Primary Accession #

P00390

UniProt Secondary Accession #

Q7Z5C9; Q9NP63; C8KIL8; C8KIL9; C8KIM0; D3DSV3

UniProt Related Accession #

P00390

GenBank Nucleotide #

NM_000637.3

NCBI Official Full Name

glutathione reductase, mitochondrial isoform 1

NCBI Official Synonym Full Names

glutathione reductase

NCBI Official Symbol

GSR

NCBI Official Synonym Symbols

HEL-75

UniProt Protein Name

Glutathione reductase, mitochondrial

Protein Family

Glutathione reductase

UniProt Gene Name

GSR

UniProt Synonym Gene Names

GLUR; GRD1; GR; GRase

UniProt Entry Name

GSHR_HUMAN

NCBI Protein Information

glutathione reductase, mitochondrial

NCBI Summary for GSR

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

UniProt Comments for GSR

GSR: a class-I pyridine nucleotide-disulfide oxidoreductase. Maintains high levels of reduced glutathione in the cytosol. Alternative initiation results in a mitochondrial and a cytoplasmic isoform.

Protein type: EC 1.8.1.7; Oxidoreductase; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: mitochondrial matrix; cytosol; external side of plasma membrane

Molecular Function: mercury (II) reductase activity; electron carrier activity; FAD binding; mercury ion binding; glutathione-disulfide reductase activity; NADP binding

Biological Process: response to reactive oxygen species; glutathione metabolic process; nucleobase, nucleoside and nucleotide interconversion; cell redox homeostasis; nucleobase, nucleoside and nucleotide metabolic process; detoxification of mercury ion

Research Articles on GSR

1. GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GSR active protein

Reference Product	PubMed Publications
CAT active protein	>50 publications with GSR and CAT
TXN active protein	>11 publications with GSR and TXN
GSS active protein	>9 publications with GSR and GSS
GSTP1 active protein	>6 publications with GSR and GSTP1
GSTA1 active protein	>3 publications with GSR and GSTA1
GSTM1 active protein	>3 publications with GSR and GSTM1
GSTT1 active protein	>2 publications with GSR and GSTT1
GGT1 active protein	>2 publications with GSR and GGT1
GSTO1 active protein	>1 publications with GSR and GSTO1

Pathways associated with GSR active protein

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Oxidative Stress Pathway antibodies	Oxidative Stress Pathway Diagram

Diseases associated with GSR active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>83 publications with GSR and Nervous System Diseases
Cardiovascular Diseases Antibodies	>51 publications with GSR and Cardiovascular Diseases
Neurobehavioral Manifestations Antibodies	>27 publications with GSR and Neurobehavioral Manifestations
Liver Diseases Antibodies	>21 publications with GSR and Liver Diseases
Disease Models, Animal Antibodies	>15 publications with GSR and Disease Models, Animal
Inflammation Antibodies	>14 publications with GSR and Inflammation
Necrosis Antibodies	>13 publications with GSR and Necrosis
Drug-Induced Liver Injury Antibodies	>12 publications with GSR and Drug-Induced Liver Injury
Poisoning Antibodies	>11 publications with GSR and Poisoning
Drug-Related Side Effects and Adverse Reactions Antibodies	>10 publications with GSR and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with GSR active protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>460 publications with GSR and Skin
Blood Antibodies	>148 publications with GSR and Blood
Heart Antibodies	>104 publications with GSR and Heart
Brain Antibodies	>77 publications with GSR and Brain
Liver Antibodies	>37 publications with GSR and Liver
Kidney Antibodies	>28 publications with GSR and Kidney
Vascular Antibodies	>22 publications with GSR and Vascular
Nerve Antibodies	>20 publications with GSR and Nerve
Eye Antibodies	>20 publications with GSR and Eye
Lung Antibodies	>16 publications with GSR and Lung