Decorin/Bone Proteoglycan II (DCN) Active Protein

Name: DCN Active Protein; Decorin/Bone Proteoglycan II; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845206
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845206

Background: Decorin, also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Decorin/Bone proteoglycan II (DCN), Active Protein

Full Product Name

Human CellExp Decorin / Bone proteoglycan II, human recombinant

Product Gene Name

DCN active protein

Product Synonym Names

Decorin; DCN; CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B.

Host

HEK293 cells

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

This protein fused with 6×His tag at the C-terminus, has a calculated MW of 38.8 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 45 kDa or higher due to different glycosylation.

OMIM

125255

3D Structure

ModBase 3D Structure for P07585

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its ability to modulate collagen fibrillogenesis. At 5 ug/mL, rh Decorin can significantly delay the rate of type I collagen fibrillogenesis.

Results

Measured by its ability to modulate collagen fibrillogenesis. At 5 ug/mL, rh Decorin can significantly delay the rate of type I collagen fibrillogenesis.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for DCN active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsCytokines; Growth Factors & Hormones; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes

Applications Tested/Suitable for DCN active protein

SDS-PAGE

Other Notes

Small volumes of DCN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCN purchase

MBS845206 is an active protein targeting DCN. Also known as Human CellExp Decorin / Bone proteoglycan II, human recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.

NCBI GI #

4503271

NCBI GeneID

1634

NCBI Accession #

NP_001911.1

UniProt Primary Accession #

P07585

UniProt Secondary Accession #

Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9

UniProt Related Accession #

P07585

GenBank Nucleotide #

NM_001920.3

NCBI Official Full Name

decorin isoform a preproprotein

NCBI Official Synonym Full Names

decorin

NCBI Official Symbol

DCN

NCBI Official Synonym Symbols

CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B

UniProt Protein Name

Decorin

UniProt Synonym Protein Names

Bone proteoglycan II; PG-S2; PG40

Protein Family

Decorin

UniProt Gene Name

DCN

UniProt Synonym Gene Names

SLRR1B

UniProt Entry Name

PGS2_HUMAN

NCBI Protein Information

decorin

NCBI Summary for DCN

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for DCN

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; proteinaceous extracellular matrix; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; wound healing; glycosaminoglycan metabolic process; pathogenesis; response to lipopolysaccharide; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; chondroitin sulfate catabolic process; carbohydrate metabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development

Disease: Corneal Dystrophy, Congenital Stromal

Research Articles on DCN

1. The results suggest that regions within decorin is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DCN active protein

Reference Product	PubMed Publications
TGFB1 active protein	>87 publications with DCN and TGFB1
VCAN active protein	>71 publications with DCN and VCAN
EGFR active protein	>22 publications with DCN and EGFR
MET active protein	>14 publications with DCN and MET
TGFB2 active protein	>12 publications with DCN and TGFB2
MMP2 active protein	>6 publications with DCN and MMP2
FBN1 active protein	>4 publications with DCN and FBN1
IGF1 active protein	>4 publications with DCN and IGF1

Diseases associated with DCN active protein

Disease Name	Pubmed Publications
Fibrosis Antibodies	>125 publications with DCN and Fibrosis
Disease Models, Animal Antibodies	>101 publications with DCN and Disease Models, Animal
Carcinoma Antibodies	>77 publications with DCN and Carcinoma
Inflammation Antibodies	>58 publications with DCN and Inflammation
Kidney Diseases Antibodies	>46 publications with DCN and Kidney Diseases
Lung Diseases Antibodies	>42 publications with DCN and Lung Diseases
Adenocarcinoma Antibodies	>29 publications with DCN and Adenocarcinoma
Neoplasms, Experimental Antibodies	>25 publications with DCN and Neoplasms, Experimental
Necrosis Antibodies	>24 publications with DCN and Necrosis
Liver Diseases Antibodies	>24 publications with DCN and Liver Diseases

Organs/Tissues associated with DCN active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>710 publications with DCN and Brain
Nerve Antibodies	>305 publications with DCN and Nerve
Connective Tissue Antibodies	>169 publications with DCN and Connective Tissue
Skin Antibodies	>166 publications with DCN and Skin
Bone Antibodies	>155 publications with DCN and Bone
Muscle Antibodies	>155 publications with DCN and Muscle
Vascular Antibodies	>138 publications with DCN and Vascular
Ear Antibodies	>92 publications with DCN and Ear
Kidney Antibodies	>82 publications with DCN and Kidney
Lung Antibodies	>69 publications with DCN and Lung