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Eotaxin-2/CCL24 (CCL24) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845234

Background: Eotaxin-2 also known as MPIF-2 is a CC chemokine characterized by its high chemotactic selectivity for eosinophils. MyBioSource's human eotaxin-2 is 8.8 kDa protein containing 78 amino acid residues. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Eotaxin-2/CCL24, Active Protein
Full Product Name
Eotaxin-2 / CCL24, human recombinant
Product Gene Name
CCL24 active protein
Product Synonym Names
C-C motif chemokine 24; Small-inducible cytokine A24; Myeloid progenitor inhibitory factor 2; CK-beta-6; Eosinophil chemotactic protein 2; Eotaxin-2; CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24; Eotaxin2; CCL-24.
Host
E Coli
Form/Format
The protein was lyophilized from a concentrated (1 mg/ml) sterile solution containing 20 mM PBS pH-7.4 and 0.15 M sodium chloride.
Appearance: Lyophilized protein
Purity/Purification
>=97%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
8.8 kDa
OMIM
602495
3D Structure
ModBase 3D Structure for O00175
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can be stored at 4 degree C for 1 week or -20 degree C for future use. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by its ability to chemoattract using peripheral blood eosinophils using a concentration of 50-100 ng/ml.
Results
50-100 ng/ml
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CCL24 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for CCL24 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CCL24 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL24 purchase

MBS845234 is an active protein targeting CCL24. Also known as Eotaxin-2 / CCL24, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL24. It may not necessarily be applicable to this product.

NCBI GI #
22165427
NCBI GeneID
6369
NCBI Accession #
NP_002982.2
UniProt Primary Accession #
O00175
UniProt Secondary Accession #
B2R5K2
UniProt Related Accession #
O00175
GenBank Nucleotide #
NM_002991.2
NCBI Official Full Name
C-C motif chemokine 24
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 24
NCBI Official Symbol
CCL24
NCBI Official Synonym Symbols
Ckb-6; MPIF2; MPIF-2; SCYA24
UniProt Protein Name
C-C motif chemokine 24
UniProt Synonym Protein Names
CK-beta-6; Eosinophil chemotactic protein 2; Eotaxin-2; Myeloid progenitor inhibitory factor 2; MPIF-2; Small-inducible cytokine A24
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL24
UniProt Synonym Gene Names
MPIF2; SCYA24; MPIF-2
UniProt Entry Name
CCL24_HUMAN
NCBI Protein Information
C-C motif chemokine 24

NCBI Summary for CCL24

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCL24

CCL24: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cytoskeleton organization and biogenesis; signal transduction; chemotaxis; regulation of cell shape; positive regulation of angiogenesis; cell-cell signaling; positive regulation of actin filament polymerization; eosinophil chemotaxis; positive regulation of endothelial cell proliferation; immune response; inflammatory response; positive regulation of cell migration; positive regulation of inflammatory response
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Research Articles on CCL24

1. these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL24 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CCL24 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >124 publications with CCL24 and Inflammation
 Immune System Diseases Antibodies  >102 publications with CCL24 and Immune System Diseases
 Hypersensitivity Antibodies  >95 publications with CCL24 and Hypersensitivity
 Asthma Antibodies  >92 publications with CCL24 and Asthma
 Respiratory Tract Diseases Antibodies  >91 publications with CCL24 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >83 publications with CCL24 and Lung Diseases
 Necrosis Antibodies  >28 publications with CCL24 and Necrosis
 Skin Diseases Antibodies  >24 publications with CCL24 and Skin Diseases
 Dermatitis Antibodies  >18 publications with CCL24 and Dermatitis
 Fibrosis Antibodies  >16 publications with CCL24 and Fibrosis

Organs/Tissues associated with CCL24 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with CCL24 and Liver
 Intestine Antibodies  >9 publications with CCL24 and Intestine
 Spleen Antibodies  >8 publications with CCL24 and Spleen
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