Human Recombinant PRDX1 Active Protein – Cat# MBS845240

PRDX 1 (PRDX1) Human Recombinant Active Protein

Name: PRDX1 Active Protein; PRDX 1; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS845240
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845240

Background: Peroxiredoxin-1 in humans is encoded by the PRDX1 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PRDX 1 (PRDX1), Active Protein

Full Product Name

Human Recombinant PRDX 1

Product Gene Name

PRDX1 active protein

Product Synonym Names

Peroxiredoxin 1; MSP23; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2; Thioredoxin peroxidase 2.; Human Recombinant PRDX 1

Sequence

MGSSHHHHHH SSGLVPRGSH MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK

Host

E Coli

Form/Format

1 mg/ml solution in 20 mM Tris-HCl buffer (pH 7.5) containing 20% glycerol.
Appearance: Liquid

Purity/Purification

>=90%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

24 kDa

OMIM

176763

3D Structure

ModBase 3D Structure for Q06830

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity: approximately 600-670 pmole/min/ug.

Unit Definition

Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25 degree C for 1 minute.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for PRDX1 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for PRDX1 active protein

SDS-PAGE

Other Notes

Small volumes of PRDX1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX1 purchase

MBS845240 is an active protein targeting PRDX1. Also known as Human Recombinant PRDX 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX1. It may not necessarily be applicable to this product.

NCBI GI #

320461711

NCBI GeneID

5052

NCBI Accession #

NP_001189360.1

UniProt Primary Accession #

Q06830

UniProt Secondary Accession #

P35703; Q2V576; Q5T154; Q5T155; B5BU26; D3DPZ8

UniProt Related Accession #

Q06830

GenBank Nucleotide #

NM_001202431.1

NCBI Official Full Name

peroxiredoxin-1

NCBI Official Synonym Full Names

peroxiredoxin 1

NCBI Official Symbol

PRDX1

NCBI Official Synonym Symbols

PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

UniProt Protein Name

Peroxiredoxin-1

UniProt Synonym Protein Names

Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX1

UniProt Synonym Gene Names

PAGA; PAGB; TDPX2; NKEF-A; PAG

UniProt Entry Name

PRDX1_HUMAN

NCBI Protein Information

peroxiredoxin-1

NCBI Summary for PRDX1

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

UniProt Comments for PRDX1

PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression.

Protein type: Nuclear receptor co-regulator; EC 1.11.1.15; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: extracellular space; peroxisomal matrix; mitochondrial matrix; cytoplasm; nucleolus; melanosome; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; peroxidase activity; thioredoxin peroxidase activity; heme binding

Biological Process: erythrocyte homeostasis; retinal homeostasis; regulation of stress-activated MAPK cascade; cell proliferation; response to reactive oxygen species; removal of superoxide radicals; natural killer cell mediated cytotoxicity; hydrogen peroxide catabolic process; skeletal development; regulation of NF-kappaB import into nucleus

Research Articles on PRDX1

1. PRDX1 is shown to be an independent predictor of improved outcomes in ER-positive breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX1 active protein

Reference Product	PubMed Publications
PRDX2 active protein	>41 publications with PRDX1 and PRDX2
PRDX5 active protein	>15 publications with PRDX1 and PRDX5
SOD1 active protein	>11 publications with PRDX1 and SOD1
MYC active protein	>10 publications with PRDX1 and MYC
SRXN1 active protein	>6 publications with PRDX1 and SRXN1
TXN active protein	>4 publications with PRDX1 and TXN
UBC active protein	>1 publications with PRDX1 and UBC

Pathways associated with PRDX1 active protein

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Peroxisome Pathway antibodies	Peroxisome Pathway Diagram
Peroxisome Pathway antibodies	Peroxisome Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram
TP53 Regulates Metabolic Genes Pathway antibodies	TP53 Regulates Metabolic Genes Pathway Diagram

Diseases associated with PRDX1 active protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>23 publications with PRDX1 and Lung Diseases
Inflammation Antibodies	>19 publications with PRDX1 and Inflammation
Lung Neoplasms Antibodies	>15 publications with PRDX1 and Lung Neoplasms
Liver Diseases Antibodies	>14 publications with PRDX1 and Liver Diseases
Nervous System Diseases Antibodies	>13 publications with PRDX1 and Nervous System Diseases
Necrosis Antibodies	>13 publications with PRDX1 and Necrosis
Disease Models, Animal Antibodies	>13 publications with PRDX1 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>12 publications with PRDX1 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>9 publications with PRDX1 and Breast Neoplasms
Lung Injury Antibodies	>9 publications with PRDX1 and Lung Injury

Organs/Tissues associated with PRDX1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>36 publications with PRDX1 and Blood
Lung Antibodies	>28 publications with PRDX1 and Lung
Liver Antibodies	>27 publications with PRDX1 and Liver
Brain Antibodies	>21 publications with PRDX1 and Brain
Vascular Antibodies	>19 publications with PRDX1 and Vascular
Muscle Antibodies	>12 publications with PRDX1 and Muscle
Kidney Antibodies	>11 publications with PRDX1 and Kidney
Nerve Antibodies	>9 publications with PRDX1 and Nerve
Heart Antibodies	>7 publications with PRDX1 and Heart
Embryonic Tissue Antibodies	>6 publications with PRDX1 and Embryonic Tissue